癫痫青少年伴焦虑及抑郁障碍的影响因素分析

Influencing factors related with anxiety and depression disorders in adolescents with epilepsy

目的探讨癫痫青少年发生焦虑及抑郁障碍的危险因素,为其干预提供依据。方法选取符合纳入标准的65例癫痫患儿为病例组,同期70例健康体检青少年为对照组,比较两组一般资料及抑郁自评量表(SDS)、焦虑自评量表(SAS)评分。再将病例组分为发生焦虑抑郁障碍组及未发生焦虑抑郁障碍组,观察两组研究对象的一般情况及临床特征,比较两组各指标差异,将两组差异有统计学意义的指标,使用Logistic回归方程进行多因素分析。结果病例组的SDS、SAS评分均高于对照组(P<0.05),癫痫并发抑郁及焦虑组病程、发作频率、抗癫痫药物的种数及类别与不并发焦虑及抑郁组相比,差异有统计学意义(P<0.05),Logistic回归分析提示发作频率和抗癫痫药物的种数是癫痫青少年焦虑及抑郁障碍的独立危险因素(P<0.05)。结论发作频率、使用抗癫痫药物的种数是患癫痫青少年焦虑及抑郁障碍的影响因素。规律用药及控制癫痫发作次数可能有助于青少年焦虑及抑郁症的治疗与预防。

Objective To investigate the risk factors affecting anxiety and depression in adolescents with epilepsy,and to provide evidence for intervention of it. Methods Sixty-five adolescents with epilepsy who met the inclusion criteria were selected as the case group.Another 70 healthy subjects in physical examination were selected as the control group.The depression and anxiety scores and baseline data were compared between the two groups.The patients of case group were subdivided into the anxiety and depression disorder group and no anxiety and depression disorder group.The baseline data and clinical characteristics of the two groups were observed.The difference of each index between the two groups was compared.Logistic regression equations were used for multivariate analysis of the indicators of academic significance. Results The self depression scale(SDS)and self anxiety scale(SAS)scores of the case group were higher than those of the control group(P <0.05).Comparison of the epilepsy course,the attack frequency,the number and type of antiepileptic drugs between the epilepsy complicated with depression and anxiety group and the epilepsy without depression and anxiety group showed there were statistical differences(P <0.05).Logistic regression analysis indicated that the attack frequency and number of antiepileptic drugs were independent risk factors of anxiety and depression disorder in adolescents with epilepsy(P <0.05). Conclusion Attack frequency and the number of antiepileptic drug use are influential factors of anxiety and depression disorder in adolescents with epilepsy.Regular drug use and control of the attack frequency of epilepsy benefit the treatment and prevention of epilepsy in adolescents.