雷火灸对气虚型非小细胞肺癌患者癌因性疲乏的影响

Effect of Thunder-fire Moxibustion on Cancer-related Fatigue in Patients with Non-small-cell Lung Cancer Due to Qi Deficiency

目的观察雷火灸对气虚型非小细胞肺癌(NSCLC)患者癌因性疲乏的影响。方法选取111例气虚型NSCLC患者随机分为观察组56例和对照组55例。两组均给予吉西他滨联合奈达铂治疗,对照组在此基础上采用健康教育,观察组在对照组基础上采用雷火灸治疗。观察两组治疗前和治疗1 d后、7 d后、14 d后简明疲乏量表(BFI)评分变化,及治疗前后中医证候积分、QLQ-C30评分及CD3﹢、CD4﹢T细胞水平变化,并比较两组临床疗效。结果观察组总有效率为85.7%,明显高于对照组的69.1%(P<0.05)。两组治疗后BFI评分均降低(P<0.05),观察组下降程度高于对照组(P<0.05),两组BFI评分有随时间变化而降低的趋势(P<0.05)。两组治疗后QLQ-C30评分均下降(P<0.05),观察组低于对照组(P<0.05)。两组治疗后中医证候积分及CD3﹢、CD4﹢T细胞水平均升高(P<0.05),观察组高于对照组(P<0.05)。结论雷火灸治疗气虚型NSCLC患者癌因性疲乏疗效较好,能明显改善患者临床症状,提高患者生活质量,其机制可能与升高CD3﹢及CD4﹢T细胞水平有关。

Objective To observe the effect of thunder-fire moxibustion on cancer-related fatigue in patients with non-small-cell lung cancer(NSCLC)due to qi deficiency.Method A total of 111 patients with NSCLC due to qi deficiency were randomized into an observation group of 56 cases and a control group of 55 cases.The two groups were intervened by gemcitabine plus nedaplatin treatment,the control group was by health education,the observation group was by thunder-fire moxibustion in addition.The Brief Fatigue Scale(BFI)score was evaluated in the two groups before treatment,and after 1 d,7 d and 14 d treatment,respectively.The BFI score,symptom score of traditional Chinese medicine(TCM),score of Quality of Life Questionnaire Core 30(QLQ-C30),and the levels of T cells CD3 and CD4 were observed before and after treatment,and the clinical efficacy was compared between the two groups.Result The total effective rate was 85.7%in the observation group,significantly higher than 69.1%in the control group(P<0.05).The BFI score declined after treatment in both groups(P<0.05),and the decrease was more significant in the observation group than in the control group(P<0.05).The BFI score declined with time in the two groups(P<0.05).The QLQ-C30 score decreased after treatment in the two groups(P<0.05),and was lower in the observation group than in the control group(P<0.05).The TCM symptom score and the levels of T cells CD3 and CD4 increased after treatment in both groups(P<0.05),and were higher in the observation group than in the control group(P<0.05).Conclusion Thunder-fire moxibustion can produce satisfactory efficacy in treating cancer-related fatigue in patients with NSCLC due to qi deficiency.It can significantly improve the clinical symptoms and the quality of life,and the mechanism may be associated with the up-regulation of the levels of T cells CD3 and CD4.