伴乳腺癌易感基因突变的年轻乳腺癌患者生育相关问题

Fertility management in young breast cancer patients with breast cancer gene mutations

年轻乳腺癌患者在中国所占比率较高,医疗技术的发展在延长患者生存期的同时也促使更多年轻患者面临生育问题。5%~10%的乳腺癌与遗传相关,其中约15%是由乳腺癌易感基因(breast cancer susceptibility gene,BRCA)1/2突变导致,并且BRCA基因突变常见于育龄期乳腺癌患者。尽管目前年轻乳腺癌患者生育管理策略是临床研究热点,但对伴BRCA基因突变的年轻乳腺癌患者生育相关问题的研究仍有限。本文将对BRCA基因突变与年轻乳腺癌患者生育力的相互影响进行概述,以期为这一特殊类型乳腺癌患者的生育抉择提供更多临床指导。

The proportion of young women with breast cancer(YBC)in China is high.With the development of medical technology,the survival time of these YBC patients has been largely extended which prompted more and more YBC patients to have the desire to pursue pregnancy.About 5%~10%of breast cancers are genetically related,and more than 15%of them are caused by mutations of breast cancer susceptibility gene(BRCA)1/2 which is more common in YBC patients.Although the current researches on the diagnosis,treatment and fertility management strategy of YBC have made great progress,the researches on fertility related problems of YBC with BRCA mutations are still very limited.In order to provide more clinical guidance on fertility choices for YBC with BRCA mutations,we summarize the impact of BRCA mutations on the reproductive potential of YBC and discuss the issue of fertility management in this particular type of breast cancer in this review.