新生儿25-羟维生素D及钙、磷、镁、碱性磷酸酶水平观察

Observation of levels of 25-hydroxyvitamin D, calcium, phosphorus, magnesium and alkaline phosphatase in neonates

目的:观察不同胎龄、出生体质量的新生儿25-羟维生素D及钙、磷、镁、碱性磷酸酶水平。方法:选取984例住院新生儿作为研究对象。按照不同胎龄将其划分为三组:<34周组、34~37周组和≥37周组;另按照出生体质量将其划分为三组:极低出生体质量新生儿组(<1500 g,VLBW组)、低出生体质量组(≥1500且<2500 g,LBW组)和正常出生体质量组(2500~3999 g,NBW组)。比较不同胎龄、不同出生体质量的新生儿25-羟维生素D与钙、磷、镁、碱性磷酸酶水平。结果:胎龄<34周及胎龄34~37周新生儿的25-羟维生素D、血钙、血磷水平明显低于胎龄≥37周的新生儿,碱性磷酸酶水平明显高于胎龄≥37周的新生儿,差异有统计学意义(P<0.05);不同胎龄新生儿血清镁水平差异无统计学意义(P>0.05);LBW组25-羟维生素D、血钙水平明显高于NBW组,NBW组25-羟维生素D、血钙水平明显高于VLBW组,差异有统计学意义(P<0.05);NBW组血磷水平明显高于LBW组和VLBW组,差异均有统计学意义(P<0.05);不同体质量各组血清镁及碱性磷酸酶水平差异无统计学意义(P>0.05)。结论:血清25-羟维生素D、钙、磷水平随胎龄增加而增高,而25-羟维生素D、钙在低体质量新生儿中水平最高,磷水平在正常体质量新生儿中最高,血清碱性磷酸酶水平在足月胎龄和正常体质量新生儿中最高,血清镁水平与胎龄及体质量无相关性。

Objective:To study levels of 25-hydroxyvitamin D and serum calcium,phosphorus,magnesium and alkaline phosphatase in neonates with different gestational ages and birth body weights.Methods:984 hospitalized neonates were selected as the research objects.They were divided into three groups according to the gestational age:<34 weeks group,34-37 week group,and≥37 week group.Also,they were divided into three groups according to the birth body weight:very low birth body weight group(<1500 g,VLBW group),low birth weight group(≥1500 and<2500 g,LBW group)and normal birth body weight group(2500-3999 g,NBW group).The levels of 25-hydroxyvitamin D and serum calcium,phosphorus,magnesium and alkaline phosphatase in the neonates with different gestational ages and different birth weights were compared.Results:The levels of 25-hydroxyvitamin D,blood calcium and blood phosphorus in the<34 week group and 34-37 week group were significantly lower than those in the≥37 week group,the ALP levels were significantly higher than that in the≥37 week group,and the differences were statistically significant(P<0.05).There was no significant difference in the serum magnesium levels among the neonates of different gestational ages(P>0.05).The levels of 25-hydroxyvitamin D and blood calcium in the LBW group were significantly higher than those in the NBW group,the levels of 25-hydroxyvitamin D and blood calcium in the NBW group were significantly higher than those in the VLBW group,and the differences were statistically significant(P<0.05).The blood phosphorus level in the NBW group was significantly higher than those in the LBW group and the VLBW group,and the differences were statistically significant(P<0.05).There were no significant differences in the serum magnesium and alkaline phosphatase levels among the different body weight groups(P>0.05).Conclusions:The levels of serum 25-hydroxyvitamin D,calcium,and phosphorus increase with the gestational age.The levels of 25-hydroxyvitamin D and calcium are the highest in the neonates with low body weight,the phosphorus level is the highest in those with normal body weight,and the serum ALP level is the highest in those with full-term gestational age and normal body weight.Further,there are no correlations among serum magnesium level and gestational age as well as body weight.