间充质干细胞在炎症性肠病治疗中的研究进展

Research progress of mesenchymal stem cells in the treatment of inflammatory bowel disease

现代医学研究表明炎症性肠病的发病机制与患者免疫失调具有密切关系。目前临床对于炎症性肠病治疗主要原则为消除活动性炎症以及改善免疫功能紊乱,比如氨基水杨酸制剂、免疫抑制剂以及糖皮质激素等均是临床治疗常用药物。间充质干细胞为具有自我复制以及多方向分化潜能的成体干细胞,对于组织修复以及免疫调节等均具有良好的治疗效果,目前在心肌梗死以及系统性红斑狼疮等疾病治疗中应用较为广泛。近些年很多专家将间充质干细胞应用于炎症性肠病的治疗中,取得了良好的效果。本文将这些新研究进展进行综述,以期为炎症性肠病的临床治疗提供借鉴。

Modern medical research shows that the pathogenesis of inflammatory bowel disease is closely related to immune disorders.At present,the main principles of clinical treatment for inflammatory bowel diseases are eliminating active inflammation and improving immune dysfunction,such as aminosalicylic acid,immunosuppressive agents and glucocorticoids,which are commonly used in clinical treatment.Mesenchymal stem cells(MSCs)are adult stem cells with self-replication and multi-directional differentiation potential.They have good therapeutic effects on tissue repair and immune regulation.They are widely used in the treatment of myocardial infarction and systemic lupus erythematosus.In recent years,many experts have applied mesenchymal stem cells to the treatment of inflammatory bowel disease,and achieved good results.This article reviews these new research advances in order to provide a reference for the clinical treatment of inflammatory bowel disease.