辛伐他汀治疗老年高血脂症对患者TG、TC变化的影响效果分析

Analysis of effect of simvastatin on changes of TG and TC in elderly patients with hyperlipidemia

目的研究辛伐他汀治疗老年高血脂症对患者TG、TC变化的影响效果。方法本次纳入2017年8月~2018年7月收治的94例老年高血脂症患者展开研究,按照随机数字表法分为两组,对照组47例予以小剂量辛伐他汀治疗,观察组47例予以大剂量辛伐他汀治疗。将两组的血脂指标、不良反应发生情况进行比对。结果观察组老年高血脂症患者治疗后的TC、TG、LDL-C水平明显低于对照组,HDL-C高于对照组,差异具有统计学意义(P<0.05);两组的不良反应发生率进行比较,差异无统计学意义(P>0.05)。结论同小剂量辛伐他汀进行比较,大剂量辛伐他汀应用于老年高血脂症患者中具有更显著的调脂效果,且安全性较高。

Objective To study the effect of simvastatin on the changes of TG and TC in elderly patients with hyperlipidemia.Methods This study included 94 elderly patients with hyperlipidemia admitted to our hospital from August 2017 to July 2018 and was divided into two groups according to the random number table method.47 patients in the control group were treated with low-dose simvastatin and 47 patients in the observation group were treated with highdose simvastatin.The blood lipid indexes and adverse reactions of the two groups were compared.Results The levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group,and hdl-c was higher than those in the control group,with statistically significant difference(P<0.05).The incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Compared with low-dose simvastatin,high-dose simvastatin has more significant lipid-regulating effect in elderly patients with hyperlipidemia,and is safe.