NT-proBNP对STEMI患者急诊PCI术后临床结果的预测价值

Predictive value of NT-proBNP in clinical outcomes of patients with STEMI after emergency PCI

目的探讨N-末端脑钠肽前体(NT-proBNP)对ST段抬高型急性心肌梗死(STEMI)患者急诊经皮冠脉介入(PCI)术后临床结果的预测价值。方法选取2018年10月~2019年3月在某院行急诊PCI术的40例STEMI患者进行研究,采用酶联免疫吸附法检测患者NT-proBNP水平,同时采用超声心动图检测患者左室射血分数(LVEF)、左室收缩末期容积指数(LVESVI)、左室舒张末期容积指数(LVEDVI),随访6个月,根据患者是否出现心血管事件分为甲组(n=30,未出现心血管事件)与乙组(n=10,出现心血管事件),对两组一般资料以及入院时、术后1周、1个月、3个月和6个月的NT-proBNP水平、LVEF、LVESVI、LVEDVI进行统计比较。结果两组性别、年龄、高血压数据比较差异不显著(P>0.05);甲组前壁心肌梗死、糖尿病发病率及入院时NT-proBNP水平均低于乙组,差异有统计学意义(P<0.05)。术后1个月和3个月,甲组NT-proBNP水平、LVESVI均低于乙组,LVEF高于乙组,差异有统计学意义(P<0.05);在LVEDVI方面,两组比较无显著差异(P>0.05)。结论STEMI患者急诊PCI术后NT-proBNP水平显著降低,且对心血管事件发生有着一定的预测价值。

Objective To study the predictive value of NT-proBNP in clinical outcomes of patients with STEMI after emergency PCI.Methods 40 patients with STEMI undergoing emergency PCI in our hospital from October 2018 to March 2019 were enrolled in the study.The levels of NT-proBNP were measured by ELISA,and LVEF,LVESVI,LVEDVI was measured by echocardiography,followed up for 6 months,according to whether patients with cardiovascular events were divided into group A(n=30,no cardiovascular events)and group B(n=10,cardiovascular events),Statistical data were compared between the two groups of general data and NT-proBNP levels,LVEF,LVESVI,and LVEDVI at admission,1 week,1 month,3 months,and 6 months after surgery.Results There were no significant differences in gender,age and hypertension between the two groups(P>0.05).The anterior wall myocardial infarction,diabetes incidence,and NT-proBNP levels were lower in group A than in group B,and the difference was statistically significant(P<0.05).At 1 month and 3 months after operation,the levels of NT-proBNP and LVESVI in group A were lower than those in group B,and LVEF was higher than that in group B(P<0.05).In LVEDVI,there was no significant difference between the two groups(P>0.05).Conclusion NT-proBNP levels are significantly lower in patients with STEMI after emergency PCI and have a predictive value for cardiovascular events.