抗HPV生物蛋白敷料对LEEP术后持续HR-HPV感染的临床观察

Clinical observation of anti-HPV biological protein dressing for continuous HR-HPV infection after LEEP

目的分析抗HPV生物蛋白敷料对LEEP术后持续HR-HPV感染的临床效果。方法选取2016年1月~2018年1月期间在某院治疗的90例LEEP术后持续HR-HPV感染患者,随机分成两组,观察组(术后给予抗HPV生物蛋白敷料,n=45)和对照组(术后未采用任何药物进行治疗和干预,n=45),对比两组患者临床效果。结果随访1年,观察组术后3个月(71.11%)、6个月(60.00%)、9个月(42.22%)、12个月(17.78%)HPV阳性率明显低于对照组(88.89%、80.00%、66.67%、40.00%),两组数据对比差异明显(P<0.05);观察组患者术后6个月、9个月、12个月HPV-DNA负荷量明显降低,与对照组相比差异具有统计学意义(P<0.05)。结论LEEP术后持续HR-HPV感染患者给予抗HPV生物蛋白敷料治疗,可降低HR-HPV持续感染风险,临床效果显著。

Objective To analyze the clinical effect of anti-HPV bioprotein dressing on continuous HR-HPV infection after LEEP.Methods A total of 90 patients with HR-HPV infection who underwent LEEP in our hospital from January 2016 to January 2018 were randomly divided into 2 groups.The observation group(postoperative anti-HPV biological protein dressing,n=45)The control group and the control group(no treatment or intervention with any drugs,n=45),compared the clinical effects of the two groups.Results One year follow-up,the positive rate of HPV in the observation group was significantly lower than that of the control group at 3 months(71.11%),6 months(60.00%),9 months(42.22%),and 12 months(17.78%)(88.89).%,80.00%,66.67%,40.00%,the difference of data between the two groups was significant(P<0.05);the HPV-DNA load of the observation group was significantly decreased at 6 months,9 months and 12 months after operation,and the control The difference between the groups was statistically significant(P<0.05).Conclusion Patients with persistent HR-HPV infection after LEEP can be treated with anti-HPV biological protein dressing,which can reduce the risk of persistent infection of HR-HPV.The clinical effect is significant.