痰湿型多囊卵巢综合征性激素结合球蛋白的相关性研究

Correlation between sex hormone binding globulin and phlegm-damp patients of polycystic ovary syndrome

目的探讨痰湿型多囊卵巢综合征(PCOS)患者性激素结合球蛋白(SHBG)水平与临床、生化特征的相关性。方法对符合纳入标准的260例PCOS患者依据痰湿证诊断标准分为痰湿组(188例)和非痰湿组(72例),根据性激素结合球蛋白(SHBG)水平将2组分别分为低值组和正常值组各2个亚组,比较痰湿型和非痰湿型及痰湿组中低值组和正常值组PCOS患者临床特征、性激素水平、糖脂代谢水平的差异,并分析其相关性。结果临床特征比较中,体重指数(BMI)和腰臀比(WHR)在痰湿组高于非痰湿组,在痰湿组中,低值组高于正常值组;痰湿组与非痰湿组比较,痰湿组睾酮(T)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、空腹血糖(FPG)、空腹胰岛素(FINS)水平及稳态模型胰岛素抵抗指数(HOMA-IR)指数高于非痰湿组,促黄体激素(LH)/促卵泡激素(FSH)比值低于非痰湿组;痰湿组中,低值组T、硫酸脱氢表雄酮(DHEAS)、TC、TG、LDL、FPG、FINS水平及HOMA-IR指数高于正常值组;痰湿型PCOS患者SHBG与BMI、WHR、T、DHEAS、TG、LDL、FPG、FINS和HOMA-IR呈负相关,与HDL呈正相关。结论痰湿型PCOS患者中,低SHBG水平更易发生肥胖、雄激素水平升高及糖脂代谢异常。

Objective To investigate the correlation between sex hormone binding globulin(SHBG)levels and clinical and biochemical characteristics in phlegm-damp patients with polycystic ovary syndrome(PCOS).Methods A total of 260 patients with PCOS were divided into phlegm-damp group(188 cases)and non-phlegm-damp group(72 cases)according to the standard of phlegm-damp syndrome.Then according to the SHBG level,the two groups were divided into two subgroups:low value group and normal group.The clinical characteristics,sex hormones,glucose and lipid metabolism were compared,then their correlation in different group were analyzed.Results In the comparison of the clinical features,BMI and WHR were higher in the phlegm-damp group than those in the non-phlegm-damp group.In the phlegm-damp group,BMI and WHR in the low value group were higher than those in the normal group.The levels of T,TC,TG,LDL,FPG,FINS and HOMA-IR were higher in phlegm-damp group than those in non-phlegm-damp group.The ratio of LH/FSH was lower than that in the non-phlegm-damp group,in the phlegm-damp group,the level of T,DHEAS,TC,TG,LDL,FPG,FINS and HOMA-IR in the low value group were higher than those in the normal group.SHBG in the phlegm-damp group was negatively correlated with BMI,WHR,T,DHEAS,TG,LDL,FPG,FINS and HOMA-IR,and positively correlated with HDL.Conclusion In the patients of PCOS with phlegm-damp syndrome,low SHBG levels are more prone to obesity,elevated androgen levels and abnormal glucose and lipid metabolism.