神经内科住院患者血清同型半胱氨酸、叶酸和维生素B12水平分析

Serum Level of Homocysteine,Folic Acid,and Vitamin B 12 in Inpatients with Neurological Disease

目的分析神经内科住院患者血清同型半胱氨酸(homocysteine,Hcy)、叶酸和维生素B 12的总体水平。方法选取2018年12月—2019年2月收治的首次诊断神经内科疾病的500例,均于入院第2日晨起检测血清Hcy、叶酸和维生素B 12水平,利用Pearson相关性分析观察Hcy与叶酸和维生素B 12的相关性。结果Hcy水平为6.50~70.10(23.57±0.47)μmol/L,叶酸水平为0.64~18.48(4.74±0.13)ng/ml,维生素B 12水平为83.00~1475.00(354.40±9.61)pg/ml。Hcy水平升高375例,叶酸水平降低162例,维生素B 12水平下降75例,分别占75.00%、32.40%、15.00%,其中Hcy水平升高合并叶酸水平下降117例,Hcy水平升高合并维生素B 12水平下降40例,Hcy水平升高合并叶酸与维生素B 12水平下降31例,没有出现叶酸和维生素B 12同时下降而Hcy水平不高的病例,单纯Hcy水平升高187例,单纯叶酸水平下降14例,单纯维生素B 12水平降低4例。Pearson相关性分析显示,Hcy与叶酸、维生素B 12均呈显著负相关,差异有统计学意义(P<0.01)。结论神经内科住院患者Hcy水平升高的发生率高,且部分患者Hcy水平升高与叶酸或维生素B 12缺乏有关。

Objective To analyze the overall level of the serum homocysteine(Hcy),folic acid and vitamin B 12 in inpatients with neurological disease.Methods A total of 500 patients with neurological disease who were initially diagnosed and treated in Neurology Department of our hospital from December 2018 to February 2019 were enrolled.All patients were tested for serum Hcy,folic acid,and vitamin B 12 levels on the morning of the second day of admission,and Pearson correlation analysis was performed to observe the correlation between Hcy and folic acid and vitamin B 12.Results The levels of serum Hcy,folic acid and vitamin B 12 were 6.50-70.10(23.57±0.47)μmol/L,0.64-18.48(4.74±0.13)ng/ml and 83.00-1475.00(354.4±9.61)pg/ml.And 375 patients were detected with elevated serum Hcy,accounting for 75%of the patients in this study.Besides,reduced levels of folic acid and vitamin B 12 were reported in 162(32.4%)and 75(15.0%)patients,respectively.Of them,the reduction of folic acid accompanied with the elevation of Hcy were detected in 117 cases,40 cases were found to have elevated Hcy and reduced vitamin B 12.Most importantly,31 patients had reduced both folic acid and vitamin B 12 and elevated level of Hcy.However,no patient had reduced folic acid and vitamin B 12 but normal Hcy level.There were still 187 cases with the elevation of Hcy but no reduction of folic acid or vitamin B 12.And 14 cases had reduced folic acid and 4 cases had reduced vitamin B 12 alone.Pearson correlation analysis showed that Hcy was negatively correlated with folic acid and vitamin B 12(P<0.01).Conclusion Serum level of Hcy in inpatients with neurological disease tends to be elevated,which may be partially due to the deficiency of folic acid or vitamin B 12.