补肾益气法治疗绝经后骨质疏松症43例

Treating 43 Cases of Postmenopausal Osteoporosis by Kidney-tonifying Qi-invigorating Method

目的:观察补肾益气法治疗绝经后骨质疏松症的临床疗效及对细胞因子和骨代谢水平的影响。方法:将86例患者按照随机数字表法分为观察组与对照组,每组43例。对照组采用常规西医治疗,观察组在对照组基础上服用补肾益气方,1剂/d,水煎分服。2组均连续治疗3个月。比较2组临床疗效,治疗前后骨密度、骨代谢和细胞因子变化情况。结果:总有效率观察组为86.05%(37/43),对照组为65.12%(28/43),2组比较差异有统计学意义(P<0.05)。治疗后L2~4、Wards三角和股骨颈骨密度2组均增加(P<0.05)且观察组高于对照组(P<0.05)。骨碱性磷酸酶(BALP)治疗后2组均增加(P<0.05),抗酒石酸酸性磷酸酶5b(TRACP-5b)治疗后2组均降低(P<0.05);观察组治疗后BALP高于对照组而TRACP-5b低于对照组(P<0.05)。2组治疗后胰岛素样生长因子1(IGF-1)增加而肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)降低(P<0.05);观察组治疗后IGF-1高于对照组而TNF-α和IL-6低于对照组(P<0.05)。结论:补肾益气法治疗绝经后骨质疏松症患者疗效显著,可改善患者细胞因子和骨代谢水平。

Objective:To observe clinical effects of kidney-tonifying Qi-invograting method in the treatment for postmenopausal osteoporosis(PMO),and its influence on the levels of cell factors and bone metabolism.Methods:All 86 patients were allocated to the observation group and the control group according to random table method,43 cases each group.The control group adopted conventional Western medicine,and the observation group took kidney-tonifying Qi-invograting prescription based on conventional Western medicine,one dose each day,water decocted.Both groups were treated for three consecutive months.To compare clinical effects between both groups,bone density,bone metabolism and cell factors before and after treating.Results:Total effective rate of the observation group was 86.05%(37/43),higher than 65.12%(28/43)of the control group,and the difference could be found between both groups(P<0.05).After treating,bone density of L2~4,Wards triangle and femoral neck in both groups increased(P<0.05);the observation group was higher than the control group(P<0.05).Bone alkaline phosphatase(BALP)lifted in both groups after treating(P<0.05).Tartrate resistant acid phosphatase-5 b(TRACP-5 b)lowered in both groups after treating(P<0.05);BALP of the observation group after treating higher than that of the control group,while TRACP-5 b lower than that of the control group(P<0.05).After treating,insulin-like growth factor-1(IGF-1)increased in both groups,while tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)reduced(P<0.05);after treating,IGF-1 of the observation group was higher than that of the control group,while the levels of TNF-αand IL-6 lower than these of the control group(P<0.05).Conclusion:Kidney-tonifying Qi-invograting method is effective in the treatment for PMO,it could improve the levels of cell factors and bone metabolism.