复方丹参注射液联合拉贝洛尔对子痫患者肝功能与胎盘生长因子的影响

Effect of Compound Danshen injection combined with Labetalol on liver function and placental growth factor in patients with eclampsia

目的:探讨复方丹参注射液联合拉贝洛尔对子痫患者肝功能与胎盘生长因子的影响。方法:选取70例子痫患者,随机分为对照组和观察组各35例。对照组采用拉贝洛尔进行治疗,观察组在对照组的治疗基础上联合复方丹参注射液治疗,联合分析两组肝功能[丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)]、血液流变学指标、胎盘生长因子(PLGF)、血清胰岛素样生长因子-1(IGF-1)及临床指标情况。结果:治疗后,观察组患者丙氨酸转氨酶(ALT)、谷草转氨酶(AST)水平显著低于对照组,观察组总蛋白(TP)、白蛋白(ALB)水平显著高于对照组,差异有统计学意义(P<0.05);观察组治疗后高切及低切全血黏度,血浆黏度及红细胞刚性指数评估指标明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后PLGF及IGF-1评估指标水平高于对照组,差异有统计学意义(P<0.05);观察组治疗后生产孕周、新生儿体重指标、胎盘重量及新生儿1 min Apgar评分情况高于对照组,差异有统计学意义(P<0.05)。结论:对子痫患者采用复方丹参注射液联合拉贝洛尔治疗,可有效控制患者的病情,改善患者的肝功能及胎盘生长因子状况,且安全性较高。

Objective:To explore the effect of Compound Danshen Injection combined with Labetalol on liver function and placental growth factor in patients with eclampsia.Methods:Totally 70 patients with eclampsia who were treated in the Hospital from February 2017 to February 2019 were enrolled.The patients were divided into two groups according to the random number table,with 35 cases in each group.The Observation group was treated with Labetalol,and the combined therapy group was treated with Compound Danshen Injection combined with Labetalol.The liver function(alanine aminotransferase,aspartate aminotransferase,total protein,and albumin),hemorheology indicators,placental growth factor and serum insulin-like growth factor-1 and clinical indicators in the two groups were analyzed.Results:After treatment,the levels of alanine aminotransferase and aspartate aminotransferase in the combined therapy group were significantly lower than those in the observation group.The levels of total protein and albumin in the combined therapy group were significantly higher than those in the observation group(P<0.05).After treatment,the high-cut and low-cut whole blood viscosity,plasma viscosity and erythrocyte rigidity index in the combined therapy group were significantly lower than the observation group,and the difference was statistically significant(P<0.05).After treatment,the levels of PLGF and IGF-1 in the combined therapy group were significantly higher than those in the observation group,and the difference was statistically significant(P<0.05).After treatment,the gestational age,neonatal weight index,placental weight and neonatal 1 min Apgar score in the combined therapy group were significantly higher than the Observation group,and the difference was statistically significant(P<0.05).Conclusion:For patients with eclampsia,compound Danshen injection combined with Labetalol is with great safety,which can help stabilize their condition,and improve their liver function and placental growth factor status.