胰岛素抵抗状态下肝脏脂质合成增加的研究进展

Advances in molecular mechanisms for enhanced hepatic lipogenesis in insulin resistance

肝脏选择性胰岛素抵抗是胰岛素抵抗状态下,胰岛素在肝脏不能抑制糖异生进而导致葡萄糖产生增加,但同时脂质合成过程保持亢进的状态。正是这种亢进状态导致2型糖尿病患者除高血糖外还伴随高血脂。本文通过固醇调节因子结合蛋白1c(SREBP1c)、哺乳动物雷帕霉素靶复合体1(mTORC1)、内质网应激、FOXO1、脂质合成底物等促进肝脏脂质合成的相关研究,综述胰岛素抵抗状态下肝脏脂质合成增加的分子机制研究进展。

Hepatic selective insulin resistance refers to that insulin fails to suppress hepatic glucose production but continues to promote hepatic lipogenesis in insulin resistance.Therefore,type 2 diabetes mellitus is characterized with dyslipidemia apart from hyperglycemia.This review highlights the roles and molecular mechanisms of the key hepatic lipogenesis factors such as sterol regulatory factor binding protein 1 c(SREBP1 c),mammalian rapamycin target complex 1(mTORC1),endoplasmic reticulum stress(ER stress),FoxO1,lipid synthesis substrate,etc.