Wnt信号通路在神经病理性疼痛中的作用及机制研究进展

Research progress on the role and mechanism of Wnt signaling pathway in neuropathic pain

神经病理性疼痛(neuropathic pain,NP)作为一种慢性疼痛综合征,严重危害患者生活质量,且发病机制复杂,临床疗法有限,极易复发。越来越多的报道发现Wnt信号通路与神经病理性疼痛的发生和发展密切相关。因此,对Wnt信号通路的进一步研究可能为探索NP的发病机制及发现有效治疗手段提供新思路。本文就Wnt信号通路在神经病理性疼痛中的作用及机制进行综述。

Neuropathic pain(NP),as a kind of chronic pain syndrome,seriously endangers the quality of life of patients,and the pathogenesis is complex,clinical treatment is limited,and it is easy to relapse.More and more reports have found that Wnt signaling pathway is closely related to the occurrence and development of neuropathic pain.Therefore,further study of the Wnt signaling pathway may provide useful ideas for exploring the pathogenesis of NP and discovering effective treatment methods.This article reviews the role and mechanism of Wnt signaling pathway in neuropathic pain.