结核分枝杆菌相关毒力因子研究进展

Research progress on related virulence factors of Mycobacterium tuberculosis

在宿主环境长期演化的过程中,结核分枝杆菌通过逃避和修改宿主对感染的反应,能完全或部分适应在宿主细胞内的存活。促进该病原体成功入侵宿主细胞的因素很多,过去几十年的大量研究使人们对结核分枝杆菌复杂的发病机制有了更深入的了解,其独特的Ⅶ型分泌系统及其细胞膜的多种复合脂质已成为这方面关注最多的热点。本综述总结了近年来结核分枝杆菌相关毒力因子的研究结果,期望从这些毒力因子中寻找新的药物靶标。

During the long-term evolution of the host environment,Mycobacterium tuberculosis can completely or partially adapt to survive in the host cells by avoiding or modifying the host response to infection.Many factors contribute to the successful invasion of this pathogen into host cells.Over the past few decades,a great deal of researches have led to deeper understanding of the complex pathogenesis of Mycobacterium tuberculosis,especially its unique Ⅶ secretion system and the cell membrane with a variety of complex lipid have become the hot topic of the aspects.This review summarizes the recent research results of Mycobacterium tuberculosis associated virulence factors,hoping to find new drug targets from these virulence factors.