摘要
Type 1 diabetes(T1D)results from dysfunction of pancreatic isletsβcells.Recent studies supported that endoplasmic reticulum(ER)stress takes an important role in pancreaticβcell excessive loss,resulting in T1D.Here,we aimed to review the relationship between ER stress and T1D.Additionally,we also reviewed the potential mechanisms underlying ER stress mediated T1D.Studies have shown that severe ER stress is directly involved in the pancreaticβcells destruction and pathogenesis of T1D.ER stress plays a key part in pancreaticβcells and T1D,which will help in developing new effective therapeutics for T1D.
基金
This work was supported by grants from the National Natural Science Foundation of China(No.41877390)
the Nature Science Fund of Hunan Province(Nos.2016JJ2113,2018JJ3458,2019JJ40241)
the Science Fund of Hunan Provincial Education Department(No.16A186)
the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study(No.0223-0002-0002000-54)
the Graduate Education and Innovation Fund of University of South China(No.2017JG022).
