联合接种和联合疫苗研究进展

A review of combined immunization:current research situation and its promising future

联合免疫包括使用联合疫苗(多联疫苗和多价疫苗)和用多种疫苗进行联合接种,其目的是通过减少前往接种点接种疫苗的次数,从而提高受种者的依从性和接种率,使更多人群受惠于疫苗的保护。本文梳理了目前国内外联合疫苗的使用现状和研发进展,对已完成和正在开展的若干项联合接种研究进行了归纳汇总,并依据我国现行免疫规划程序中接种疫苗的时间重叠情况,提出下一步开展联合接种研究的需求展望,为进一步优化免疫程序、研发新的联合疫苗提供新的思路。

Combined immunization consists of combined vaccines(including polyvalent vaccines)and simultaneous administration of vaccines,aiming to reduce unnecessary inoculating times for children,and to broaden immunization coverage and a significant larger group of population would be benefit from the Expanded Program on Immunization.In this review,we have summarized a list of research papers focused on combined immunization.By scrutinizing the safety and effectiveness outcomes of combined immunization,we provide some suggestions about upgrading the current immunization program as well as research and development of new combined vaccines.