杯芳烃在液相色谱固定相领域的应用及进展

Application of calixarene stationary phases to liquid chromatography

杯芳烃是一类由苯酚单元通过亚甲基桥连的超分子化合物,具有独特的主客体识别性能,是继冠醚和环糊精之后第三代超分子化合物的主要代表。其被广泛应用于离子通道、有机催化反应、跨膜转运、纯化、色谱分离等方面。基于杯芳烃易于修饰的特点,选取不同性质的化合物进行衍生化,可以制备出具有不同识别能力和高选择性的杯芳烃衍生物,进而应用于不同色谱分离模式,可实现复杂样品的分离分析。该文从杯芳烃、杯芳烃衍生物和杯杂芳烃3个方面综述了近年来杯芳烃在液相色谱固定相方面的研究应用及进展,并对杯芳烃在色谱分离领域的发展提出了展望。

Calixarenes are cyclic oligomers composed of phenol units linked by methylene bridges. Because of their unique host-guest recognition ability, calixarenes are considered to be the main representatives of the third generation of supramolecular chemistry after crown ethers and cyclodextrins. Calixarenes are widely used in ion channel as well as in organic catalytic reactions, transmembrane transport, purification, and chromatographic separation. A variety of versatile calixarene derivatives with different recognition ability and special selectivity were prepared by modifying different types of compounds due to calixarenes are easy to derivatize. These derivatives were successfully applied to different chromatographic modes to achieve the separation and analysis of complex samples. This review summarizes the recent advances in stationary phases based on calixarenes and their derivatives for liquid chromatography The prospects of calixarenes in chromatographic separation science are also presented.