奥曲肽联合埃索美拉唑治疗肝硬化上消化道出血的临床效果

Efficacy of octreotide combined with esomeprazole on upper gastrointestinal bleeding in patients with cirrhosis

目的分析肝硬化上消化道出血患者联合应用埃索美拉唑、奥曲肽治疗的临床效果.方法抽取2014年1月至2018年12月汾西矿业集团总医院收治的100例肝硬化上消化道出血患者为回顾分析对象,采用数字法将其分为观察组和对照组.两组患者入院后立即采取常规的止血治疗,对照组在常规治疗基础上单独应用奥曲肽治疗,观察组则联用奥曲肽和埃索美拉唑进行治疗.结果经治疗后观察组患者的治疗总有效率达98.00%,高于对照组(90.00%,P<0.05);观察组患者止血时间短于对照组,同时脾静脉血流量和门静脉血流量下降幅度高于对照组(P<0.05).结论肝硬化上消化道出血患者联合应用奥曲肽和埃索美拉唑治疗可取得满意效果,有助于快速止血并提升临床疗效,且药物安全性较高.

Objective To analyze the clinical value of combined use of esomeprazole and octreotide in the treatment of patients with upper gastrointestinal bleeding in cirrhosis.Methods A total of 100 patients with upper gastrointestinal in cirrhosis in Fenxi Mining Group General Hospital from January 2014 to December 2018 were selected for retrospective analysis,they were randomly divided into observation group and control group by random number method.Patients in the two groups were treated with conventional hemostasis immediately after admission.Patients in the control group were treated with octreotide on the basis of conventional treatment,while patients in the observation group were treated with octreotide and esomeprazole.Results After treatment,the total effective rate of the observation group was as high as 98.00%,which was higher than 90.00%in the control group(P<0.05).The hemostasis time of the observation group was shorter than that of the control group,and the decrease of splenic venous blood flow and portal venous blood flow were significantly higher than those of the control group(P<0.05).Conclusions The combination of octreotide and esomeprazole in the treatment of upper gastrointestinal hemorrhage in patients with liver cirrhosis can achieve satisfactory results,contribute to rapid hemostasis and improve the clinical efficacy,and the drug safety is high.