沙丁胺醇与酮替芬联合治疗对小儿哮喘血清ET-1 NO CEC水平的影响

Effect of Salbutamol Combined with Ketotifen on Levels of Serum ET-1 NO and CEC in Children with Asthma

目的:观察沙丁胺醇与酮替芬联合治疗对小儿哮喘血清血管内皮素-1(ET-1)、一氧化氮(NO)、循环内皮细胞(CEC)水平的影响。方法:选取我院收治的80例小儿哮喘患者,按照入院顺序单双号分为两组,各40例,对照组予以常规治疗+沙丁胺醇,观察组于其基础上加用酮替芬,比较两组治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、肺活量(FVC)、FEV1/FVC、呼气峰流量(PEF)]、血清ET-1、NO、CEC水平,并观察两组症状消退时间、疗效及不良反应情况。结果:观察组治疗总有效率明显高于对照组(P<0.05);两组治疗后FEV1、FVC、FEV1/FVC、PEF均显著升高(P<0.05),且观察组升高程度明显大于对照组(P<0.05);两组治疗后血清ET-1、NO、CEC水平均显著降低,观察组降低程度明显大于对照组(P<0.05);观察组咳嗽、肺部啰音、气促以及喘憋症状消退时间均明显短于对照组(P<0.05);两组不良反应总发生比较无显著差异(P>0.05)。结论:沙丁胺醇与酮替芬联合治疗小儿哮喘,可促进肺功能与临床症状恢复,疗效确切,可能与降低血清ET-1、NO、CEC水平有关,且安全性高。

Objective:To observe the effects of salbutamol and ketotifen on serum levels of endothelin-1(ET-1),nitric oxide(NO)and circulating endothelial cells(CEC)in children with asthma.Methods:80 children with asthma enrolled in our hospital were chosen.According to the odevity of admission order,they were divided into 2 groups,40 cases in each group.The control group was given routine treatment and salbutamol,the observation group was given ketotifen on the basis of the control group.The lung function indexes[force expiratory volume in the first second(FEV1),vital capacity(FVC),FEV1/FVC,peak expiratory flow(PEF)],serum levels of ET-1,NO,CEC in the two groups before and after treatment were compared,the symptom regression time,efficacy and adverse reactions of the two groups were observed.Results:The total response rate of the observation group was significantly higher than that of the control group(P<0.05).The FEV1,FVC,FEV1/FVC and PEF of both groups increased significantly after treatment(P<0.05),and the increase in the observation group was significantly greater than that in the control group(P<0.05).However,the serum levels of ET-1,NO and CEC decreased significantly after treatment(P<0.05),and the decrease in the observation group was significantly greater than that in the control group(P<0.05).The fading away time of cough,lung rale,shortness of breath and wheezing symptoms in the observation group was significantly shorter than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P<0.05).Conclusion:Salbutamol combined with ketotifen in the treatment of children with asthma can promote recovery of lung function and clinical symptoms,which nay be related to reduction of serum ET-1,NO and CEC levels,and the safety is high.