百癣夏塔热片联合阿达帕林凝胶治疗寻常痤疮的疗效观察

Observation on Clinical Effect of Baixuanxiatare Tablet Combined with Adapalene Gel on Acne Vulgaris

目的:观察百癣夏塔热片联合阿达帕林凝胶治疗寻常痤疮的疗效。方法:选取2018年1月至2019年4月我院收治的寻常痤疮患者116例,按照入院前后顺序进行编号,随机抽取58例作为治疗组,其余58例作为对照组。对照组实施阿达帕林凝胶治疗,治疗组在对照组基础上联合应用百癣夏塔热片治疗。对比两组患者临床疗效、中医证候积分、血清睾酮(T)、雌二醇(E2)水平、皮脂分泌状况及不良反应发生率。结果:治疗组总有效率高于对照组,有统计学差异(94.83%vs70.69%,P<0.05)。治疗后两组中医证候积分均明显低于治疗前,且治疗组中医证候积分低于对照组(7.41±1.73vs13.62±1.95,P<0.05)。治疗后两组血清T水平均低于治疗前,且治疗组低于对照组(562.81±174.26vs681.93±194.17,72.52±21.48vs95.49±23.62,P<0.05);E2水平显著高于治疗前(P<0.05),且治疗组高于对照组(48.35±9.26vs43.64±6.01,128.36±28.25vs113.94±26.61,P<0.05)。两组治疗后皮脂分泌率明显低于治疗前(P<0.05),且治疗组皮脂分泌率低于对照组的(1.04±0.13vs1.39±0.21,P<0.05)。治疗组不良反应发生率与对照组的比较差异不明显(15.52%vs13.79%,P>0.05)。结论:寻常痤疮患者实施百癣夏塔热片联合阿达帕林凝胶治疗,临床疗效确切,可显著改善血清睾酮、雌二醇水平,有效抑制皮脂分泌,且安全性较高。

Objective:To observe the curative effect of Baixuanxiatare tablet combined with Adapalene Gel on acne vulgaris.Methods:116 cases of patients with acne disseminata admitted to our hospital from January 2018 to April 2019 were selected and numbered according to the order of admission,58 cases were randomly selected as the treatment group,and the other 58 cases were used as the control group.The control group was implemented Adapalene Gel treatment,the the treatment group was implemented Baixuan Xiatare Tablet treatment on the basis of control group.The clinical efficacy,TCM syndrome score,serum testosterone(T)and estradiol(E2)levels,sebum secretion status and incidence rate of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the treatment group was higher than that of the control group,with statistical difference(94.83%vs70.69%,P<0.05).Compared with before and after treatment,and the scores of TCM syndromes in the treatment group were lower than those in the control group(7.41±1.73vs13.62±1.95,P<0.05).Compared with before,the serum T levels of the two groups decreased on average,and the treatment group were lower than the control group(562.81±174.26 vs 681.93±194.17,72.52±21.48 vs 95.49±23.62,P<0.05).The E2 levels were significantly higher than the before treatment(P<0.05),the treatment group was higher than the control group(48.35±9.26 vs 43.64±6.01,128.36±28.25 vs 113.94±26.61,P<0.05).The sebum secretion rates of the two groups after treatment were significantly lower than those before treatment(P<0.05),and the sebum secretion rate of the treatment group was lower than that of the control group(1.04±0.13 vs1.39±0.21,P<0.05).There was no significant difference in the incidence of adverse reactions between the treatment group and the control group(15.52%vs 13.79%,P>0.05).Conclusion:Baixuanxiatare Tablet combined with Adapalene Gel in the treatment of acne disseminata has clinical curative effect.It can significantly improved the levels of serum testosterone and estradiol,effectively inhibits sebum secretion,and has high safety.