不良孕产史与围绝经期女性高血压病关系研究

Study on the Relationship between Adverse Pregnancy History and Hypertension in PerimeNopausal Women

目的:分析不良孕产史与围绝经期女性高血压疾病的关系,为女性心血管疾病的早期预防提供理论依据。方法:选择2018年8月至2019年8月就诊于承德医学院附属医院的40~60岁患有高血压疾病女性患者256例作为病例组,选择同期就诊的40~60岁无高血压疾病女性314例作为对照组,采用病例对照研究的方法,进行问卷调查,对研究因素进行单因素及多因素非条件logistics回归分析,结果:体重指数(OR=1.946,95%CI:1.072~3.534)、妊娠期高血压(OR=3.649,95%CI:1.064~12.510)、早产(OR=2.693,95%CI:1.179~6.152)、首次分娩年龄(OR=0.492,95%CI:0.248~0.976)。结论:调整混杂因素后,体重指数≥28kg/m2、早产、妊娠高血压疾病的人群均为围绝经期高血压的独立危险因素,首次分娩年龄在20~35岁之间的女性,为围绝经期高血压的保护因素。因此加强对围绝经期高血压人群危险因素的管理,提高高血压保护因素的认识,降低高血压的发生率。

Objective:To analyze the relationship between adverse pregnancy and perinatal hypertension,and to provide theoretical basis for the early prevention of cardiovascular disease.Method:256 female patients aged 40-60 with hypertension who visited to Affiliated Hospital Of Chengde Medical University from August 2018 to August 2019 were selected as the case group,and 314 women aged 40-60 with no hypertension were selected as the control group.Using case-control method,questionnaire survey was carried out,and single factor and multi factor unconditional logistic regression analysis was carried out.Results:Body mass index(or=3.465,95%CI:2.175-5.526),gestational hypertension(or=3.629,95%CI:1.080-12.140),premature birth(or=2.468,95%CI:1.073-5.674),age of first delivery(or=0.468,95%CI:0.233-0.938).Conclusions:After adjusting the confounding factors,the population with body mass index≥28KG/m2,preterm delivery and pregnancy induced hypertension were all independent risk factors of perimenopausal hypertension.The women with the first delivery age between 20-35 years old were the protective factors of perimenopausal hypertension.Therefore,it is necessary to strengthen the management of risk factors of perimenopausal hypertension,improve the understanding of hypertension protective factors,and reduce the incidence of hypertension.