摘要
目前临床上妊娠期用药的安全性数据较少,因此开展药物胎盘转运的研究可预测药物在体内透过胎盘屏障的转运过程,对于指导妊娠女性合理用药具有重要意义。药物胎盘转运的研究涉及体内及体外两方面。体内研究可提供较为完整的妊娠过程,但由于伦理限制和种间差异,该研究较难展开;体外研究通过建立离体胎盘灌注模型、胎盘组织制备模型和细胞培养模型,分别从细胞、组织和整体3个不同维度进行药物经胎盘转运的研究。本文综述了以上胎盘转运模型及其特点和研究进展,期望能为学者提供合适的药物胎盘转运模型以进行下一步研究。
At present,there are few data on drug safety used in pregnancy.The study of drug placental transporter can predict the transport process of drugs through the placental barrier,which is of great significance to guide the rational use of drugs in pregnant women.The method of studying placental transporters includes both in vivo and in vitro.In vivo experiment provide a more completely pregnancy process.It is more difficult to carry out due to ethical limitations and interspecific differences.In vitro models include ex vivo human placental perfusion,the membrane vesicles and villous explant model,the human choriocarcinoma cell lines.Drug placental transporter is studied from three different dimensions:cell,tissue and the whole.In this review,we are talking about the above placental transporter models and their characteristics and research progress,which are expected to provide scholars with a suitable placental transporter model for further research.
作者
马雯婷
王晶晶
王茜
李骞
黄桦
张峻
MA Wen-ting;WANG Jing-jing;WANG Xi;LI Qian;HUANG Hua;ZHANG Jun(Department of Clinical Pharmacy,The First Affiliated Hospital of Kunming Medical University,Kunming 650032 Yunnan Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第2期209-212,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金地区基金资助项目(81560252)
云南省基础研究计划(昆医联合专项)重点基金资助项目[2018FE001(-167)]
云南省教育厅科学研究基金资助项目(2017zDX166)
云南省高层次卫生计生技术人才培养专项经费基金资助项目(L-201614,H-2017050,H-2017-051,H-2017053)。
关键词
胎盘屏障
药物转运
体内模型
体外模型
placental barrier
drug-transport
in vivo models
in vitro models