葫芦素B固体分散体的制备

Preparation of cucurbitacin B solid dispersions

目的制备葫芦素B固体分散体。方法溶剂法制备固体分散体后,以溶出度为评价指标筛选药物-载体(PVP K30)比例。扫描电子显微镜(SEM)、傅里叶变换红外光谱(FTIR)、差示扫描量热(DSC)、X射线衍射(XRD)进行表征。结果药载比为1∶11时,60 min内溶出度为62.01%。葫芦素B可能以无定形状态分散于载体中。结论该方法简便可行,葫芦素B制成固体分散体后体外溶出度明显提高。

AIM To prepare cucurbitacin B solid dispersions.METHODS For the solid dispersions prepared by solvent method, drug-carrier(PVP K30) ratio screened with dissolution rate as an evaluation index. Characterization was performed by scanning electron microscope(SEM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC) and X-ray diffraction(XRD).RESULTS The dissolution rate within 60 min was 62.01% at the drug-carrier ratio of 1∶11. Cucurbitacin B may be dispersed in carrier with an amorphous phase.CONCLUSION Cucurbitacin B demonstrated obviously enhanced in vitro dissolution rate after being preparaed into solid dispersions by this simple and feasible method.