痴呆前心理行为障碍的临床表现及机制研究进展

Clinical symptoms and mechanism of psychological and behavioral impairment pre-dementia

轻度心理行为障碍(mild behavioral impairment,MBI)是一种痴呆前综合征,主要在知觉、思维、情感、行为、人格等方面表现异常,可增加个体发生痴呆的风险。痴呆的精神行为症状(behavioral and psychological symptoms of dementia,BPSD)指痴呆病程中出现的精神和行为问题,该症状的发生可增加照料负担与患者的死亡率。MBI和BPSD组成痴呆相关的神经精神症状(neuropsychiatric symptoms,NPS)。MBI作为新的概念,为轻度认知功能障碍(mild cognitive impairment,MCI)和痴呆的临床治疗与研究提供了新的视角,并引起了广泛的关注。该文回顾了MBI与NPS相关文献,综述MBI的临床表现以及与认知障碍的神经生物学联系,并提出了MBI更合理的翻译应为痴呆前心理行为障碍。

Mild behavioral impairment(MBI)is a kind of pre-dementia syndrome,which presents abnormalities in perception,thinking,emotion,behavior,personality and other aspects.At the same time,the occurrence of MBI increases the risk of dementia.Behavioral and psychological symptoms of dementia(BPSD)refers to the mental and behavioral problems of patients during the course of dementia.Meanwhile,suffering from this disease will increase the care burden of caregivers and the death rate of patients.MBI and BPSD constitute the neuropsychiatric symptoms(NPS)associated with dementia.As a new term and new concept,MBI can offer a new perspective to the clinical treatment and research of mild cognitive impairment(MCI)and dementia,which has aroused wide attention.This paper reviews the literature related to MBI and NPS,comprehensively analyzes the clinical manifestations of MBI and its relationship with the neurobiology of cognitive impairment,and proposes that MBI should be translated as pre-dementia psychosocial behavior impairment.