丁苯酞对急性脑梗死患者认知障碍的作用效果分析

Effect of butylphthalide on cognitive impairment in patients with acute cerebral infarction

目的:研究丁苯酞对急性脑梗死患者认知障碍的治疗效果。方法:选择2016年2月至2018年2月我院收治的94例急性脑梗死患者为研究对象,随机分为观察组和对照组,各47例。对照组予以常规治疗,观察组则在对照组的基础上加用丁苯酞胶囊口服治疗,所有患者均予以为期5周的治疗。比较2组在临床疗效、治疗前后神经功能缺损程度、认知功能变化情况以及不良反应等方面的差异。结果:观察组总有效率显著高于对照组(P<0.05)。治疗后,观察组NIHSS评分显著低于对照组(P<0.05),MoCA、MMSE评分显著高于对照组(P<0.05)。观察组与对照组在胃肠道反应、转氨酶升高、消化道出血发生率方面比较,差异无统计学意义(P>0.05)。结论:丁苯酞可显著改善急性脑梗死患者的认知障碍情况,同时有利于促进患者神经功能的恢复,安全性较好,可作为临床上治疗急性脑梗死的有效手段之一。

Objective:To investigate the effect of butylphthalide on cognitive impairment in patients with acute cerebral infarction(ACI).Methods:A total of 94 patients with ACI admitted to our hospital from Feb 2016 to Feb 2018 were enrolled and randomly divided into observation group and control group,with 47 cases in each group.The control group received conventional treatment,while the observation group received oral administration of butylphthalide capsules on the basis of conventional treatment.All patients were treated for 5 weeks,and the clinical efficacy,degree of neural function defect,changes of cognitive function and adverse reactions between the two groups were compared.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05),and the MoCA and MMSE scores were significantly higher that those of the control group(all P<0.05).No significant difference was found in the incidence of gastrointestinal reactions,elevation of transaminase and gastrointestinal bleeding between the two groups(P>0.05).Conclusion:The application of butylphthalide can significantly improve the cognitive impairment of patients with ACI,promote the recovery of neurological function,and it has good safety and can be used as an effective method for the treatment of ACI.