儿童Epstein-Barr病毒合并肺炎支原体感染的临床特点

Clinical characteristics and influencing factors of Epstein-Barr virus with mycoplasma pneumoniae infection in children

目的探讨儿童Epstein-Barr(EB)病毒合并肺炎支原体(MP)感染的临床特点。方法选取EB病毒合并MP感染的87例患儿为观察组,同期治疗的单纯MP感染的70例患儿为对照组。比较两组一般资料、实验室结果及临床情况等方面的差异。结果MP合并EB病毒感染以学龄前儿童居多,MP和EB病毒合并感染患儿的白细胞较单纯MP感染略升高,天冬氨酸转氨酶(AST)、丙氨酸氨基转移酶(ALT)、磷酸肌酸激酶同工酶(CK-MB)有一过性升高;合并感染儿童的肺实质性病变程度更高,更易出现胸腔积液。合并感染的患儿临床特征表现为淋巴结易肿大,发热持续时间延长。结论与单纯肺炎支原体感染相比,儿童EB病毒合并MP感染的患儿临床表现更加严重,常累及多个器官。

Objective To investigate the clinical characteristics and influencing factors of mycoplasma pneumoniae(MP)infection with Epstein-Barr(EB)virus in children.Methods The research subjects of this experiment included 87 cases of hospitalized children with EB virus complicated with MP infection as observation group.And 70 patients with simple MP infection at the same time were selected as control group.The differences in general data,laboratory results and clinical conditions between two groups were compared and analyzed.Results EB virus combined with MP infection was mostly seen in preschool children and the gender difference was not obvious.Blood routine examination showed that white blood cells of children with MP and EB virus infection were significantly higher than thoseof children with MP infection alone(P<0.05).Serum biochemistry showed transient elevation of AST,ALT and CKMB.Imageological examination suggested that the degree of pulmonary substantive lesion was higher in children with concurrent infection and pleural effusion was more likely to happen.The clinical features of children with concurrent infection showed that lymph nodes were more prone to swelling,and the extension of fever duration.Conclusion Compared with MP infection alone,the clinical manifestation of EB virus combined with MP infection is more serious and often involves multiple organs.