脑皮质表面铁沉积研究进展

Progress in Research on Cortical Superficial Siderosis

脑皮质表面铁沉积(cortical superficial siderosis,cSS)是近年来发现的含铁复合物在脑皮质表面形成的线样沉积物。cSS主要存在于淀粉样脑血管病和阿尔茨海默病患者中。其典型临床表现为短暂性局灶性神经样发作和认知功能障碍。MRI T2^*加权梯度回波序列和SWI序列检测到cSS为沿大脑沟回表面分布的线样低信号,分为局灶性cSS和播散性cSS。cSS可预测淀粉样脑血管病患者未来颅内出血风险并且与不良功能结局预后及认知功能障碍相关,有望指导临床抗血栓等治疗决策。

Cortical superficial siderosis(cSS)is linear residents of chronic blood products in the superficial layers of cerebral cortex.cSS is mainly found in patients with cerebral amyloid angiopathy(CAA)and Alzheimer’s disease.The typical clinical manifestations of patients with cSS are transient focal neurological episodes and cognitive impairment.The imaging features of cSS shows a characteristic“gyriform”pattern of low signal on MRI T2^*-weighted gradient recalled echo(T2^*-GRE)and susceptibility weighted imaging,and the distribution of cSS was classified as focal and disseminated cSS.cSS can be used to predict the risk of intracerebral haemorrhage in patients with CAA and it is associated with poor functional outcome and cognitive impairment.Therefore,cSS may have a clinical value in guidance for clinical treatment decision-makings such as antithrombotic treatment.