特异性异尖线幼虫感染IgE抗体阳性与高危妊娠的相关性分析

Correlation between the Anisakis Species-Specific IgE Positive and High-risk Pregnancy

【目的】探讨异尖线幼虫感染IgE抗体阳性与高危妊娠的相关性。【方法】选择2017年1月至2019年12月在本院诊治的高危妊娠孕妇738例(观察组),另外选择同期在本院产检健康孕妇500例作为对照组。采集所有孕妇的静脉血,检测其血清特异性异尖线幼虫IgE抗体,并分析孕妇血清IgE抗体阳性的影响因素及与高危妊娘的相关性。【结果】观察组IgE抗体阳性率为24.8%(183/738),显著高于对照组的20.0%(100/500),其差异有统计学意义(P<0.05);IgE阳性组孕妇的平均年龄显著大于IgE阴性组,顺产比例、初产比例显著低于IgE阴性组,产后住院时间显著长于IgE阴性组,妊娠期间检查次数显著少于IgE阴性组。孕妇分娩的新生儿中,IgE阳性组孕妇所产的新生儿体质量、胎龄均显著小于IgE阴性组,新生儿监护病房(NICU)患儿比例显著高于IgE阴性组。高危妊娠是孕妇异尖线幼虫感染IgE抗体阳性的独立危险因素。【结论】高危妊娠是孕妇异尖线幼虫感染IgE抗体阳性的独立危险因素,影响妊娘结局。

【Objective】 To investigate the association between the Anisakis species-specific IgE and high-risk pregnancy.【Methods】A total of 738 maternal who admitted to Wuhan fifth hospital from January 2017 to December 2019 diagnosed as high-risk pregnancy were selected as the study group,500 healthy women were selected as the control group.The basic data of the maternal and the neonatal outcome were collected,with venous blood was collected and the presence of specific anti Anisakivs IgE antibodies was detected.The differences in the maternal basic data and neonatal outcom es between two groups were compared and the related factors for the presence of specific anti Anisakis IgE antibodies were in vestigated.【Results】The proportion of IgE positive patients in the observation group was significantly higher than that in the control group[183(24.8%)vs.100(20.0%),P=0.049].The average age of women in the IgE-positive group was significantly older than that of the IgE-negative group,the proportion of women who received natural delivery was significantly lower and the rate of first birth was significantly lower in the IgE-positive group,the postpartum hospital stay was significantly longer and the times of inspection during pregnancy was significantly less in the IgE-positive group.Am ong the newborns who were delivered by IgE-positive women,the weight and gestational age were significantly less and the proportion of NICU was significantly higher than in the IgE-negative group.There was a significant correlation between IgE positive and high-risk pregnancy.【Conclusion】High-risk pregnancy is an independent risk factor for pregnant women infected by Anisakis with IgE antibody positive,which affects pregnancy outcomes.