NLR、FIB及脂蛋白A与冠脉病变程度的关系

The relationship between NLR,FIB and lipoprotein Aand the degree of coronary artery disease

目的:探讨中性粒细胞/淋巴细胞比值(NLR)、血清纤维蛋白原(FIB)及脂蛋白A与急性冠脉综合征患者冠脉病变程度的相关性.方法:选取180例行数字减影血管造影(DSA)的急性冠脉综合征患者作为研究对象,分为UA组(58例),NSTEMI组(63例),STEMI组(59例),并选取同时期100例冠脉造影正常者作为对照组.分析NLR、FIB和脂蛋白A的水平,Gensini评分与冠脉病变程度的相关性.结果:对照组与UA组、NSTEMI组及STEMI组比较,NLR、FIB、脂蛋白A水平,Gensini评分均有显著性差异;随着冠脉病变支数增加,NLR、FIB、脂蛋白A水平,Gensini评分也随之增高;NLR、FIB、脂蛋白A与Gensini评分均呈正相关.结论:NLR、FIB、脂蛋白A与冠状动脉病变严重程度具有明显相关性.

Objective:To investigate the correlation between the neutrophil to lymphocyte ratio(NLR),serum fibrinogen(FIB)and lipoprotein A and the severity of coronary stenosis in patients with acute coronary syndrome.Methods:One hundred and eighty cases of patients with acute coronary syndrome undergoing digital subtraction angiography(DSA)were randomly divided into a UA group(58 cases),a NSTEMI group(63 cases)and a STEMI group(59 cases),and meanwhile 100 patients undergoing normal coronary angiography were selected as a control group.The general situation,NLR,FIB and lipoprotein A levels and their correlation with Gensini score were analyzed.Results:There were significant differences among the control group and the UA group,the NSTEMI group and the STEMI group in the levels of NLR,FIB,lipoprotein A and Gensini score(P<0.01).The levels of NLR,FIB,lipoprotein A and Gensini score increased with the increase of the number of coronary lesions(P<0.01).NLR,FIB,lipoprotein A levels were positively correlated with Gensini score.Conclusion:NLR,FIB and lipoprotein A levels are significantly correlated with the severity of coronary artery.