卵巢癌中胰岛素样生长因子-1及其受体表达与临床病理特征的相关性

Correlation of insulin-like growth factor-1 and its receptor in ovarian cancer with clinicopathological features

目的研究卵巢癌中胰岛素样生长因子-1(insulin like growth factor-1,IGF-1)及其受体IGF-1R表达与临床病理特征、手术预后的相关性。方法采用免疫组化检测卵巢癌、卵巢交界性肿瘤、卵巢良性肿瘤中IGF-1、IGF-1R的阳性表达率,分析IGF-1、IGF-1R与临床病理特征、手术预后的相关性。结果卵巢癌中IGF-1、IGF-1R的阳性表达量率分别为65.63%、70.31%,明显高于卵巢交界性肿瘤中IGF-1、IGF-1R的阳性表达量率22.22%、16.67%及卵巢良性肿瘤中IGF-1、IGF-1R的阳性表达量率5.00%、10.00%(χ^2/P=27.548/0.000、31.335/0.000),IGF-1、IGF-1R的mRNA表达量及蛋白表达量也明显高于卵巢交界性肿瘤及卵巢良性肿瘤(F/P=31.922/0.000、26.865/0.000、34.567/0.000、27.667/0.000);国际妇产科协会(federation international of gynecology and obstetrics,FIGO)III^IV期、组织分化程度G2~G3、CA125≥35 U/ml、Ki67阳性的卵巢癌中IGF-1、IGF-1R的阳性表达率明显高于FIGO I^II期、组织分化程度G1、CA125<35 U/ml、Ki67阴性的卵巢癌(IGF-1的χ^2/P=8.505/0.004、4.980/0.026、7.481/0.006、10.907/0.001;IGF-1R的χ^2/P=9.785/0.002、4.950/0.026、7.211/0.007、6.471/0.011);卵巢癌IGF-1阳性患者的总生存时间较IGF-1阴性患者缩短。结论IGF-1、IGF-1R在卵巢癌中高表达,且与病理特征及手术预后的恶化相关。

Objective To study the correlation between insulin-like growth factor-1(IGF-1)and its receptor IGF-1R expression in ovarian cancer and clinicopathological features,surgical prognosis.Methods The positive expression rates of IGF-1 and IGF-1R in ovarian cancer,borderline ovarian tumors and benign ovarian tumors were detected by immunohistochemistry.The correlation of IGF-1 and IGF-1R with clinicopathological features,surgical prognosis was analyzed.Results The positive expression rate of IGF-1 and IGF-1R in ovarian cancer was 65.63%,70.31%,significantly higher than 22.22%,16.67%in borderline ovarian tumors,5.00%,10.00%in benign ovarian tumors(χ^2/P=27.548/0.000,31.335/0.000).The mRNA and protein expression of IGF-1 and IGF-1R were also significantly higher than borderline ovarian tumors and benign ovarian tumors(F/P=31.922/0.000,26.865/0.000,34.567/0.000,27.667/0.000).The positive expression rates of IGF-1 and IGF-1R in ovarian cancer with FIGOIII-IV stage,tissue differentiation G2-G3 stage,CA125>35 U/mL,Ki-67 positive expression were significantly higher than those in ovarian cancer with FIGOI-II stage,tissue differentiation G1 stage,CA125<35 U/mL,Ki-67 negative expression(IGF-1:χ^2/P=8.505/0.004,4.980/0.026,7.481/0.006,10.907/0.001,IGF-1R:χ^2/P=9.785/0.002,4.950/0.026,7.211/0.007,6.471/0.011).The total survival time of ovarian cancer patients with positive IGF-1 and IGF-1R was shorter than those of patients with negative IGF-1 and IGF-1R.Conclusion IGF-1 and IGF-1R are highly expressed in ovarian cancer and are associated with the deterioration of pathological features and surgical prognosis.