沙美特罗/氟替卡松联合孟鲁司特钠治疗成人咳嗽变异性哮喘的效果观察

Observation on effect of salmeterol/fluticasone combined with montelukast sodium on adult cough variant asthma

目的探讨沙美特罗/氟替卡松联合孟鲁司特钠治疗成人咳嗽变异性哮喘的临床效果。方法84例成人咳嗽变异性哮喘患者,采用简单随机抽样法分为观察组与对照组,每组42例。对照组使用沙美特罗/氟替卡松治疗,观察组在对照组基础上联合孟鲁司特钠治疗。对比两组患者的治疗效果,治疗前后第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、免疫球蛋白E(IgE)水平及早晨与夜晚咳嗽评分。结果观察组治疗总有效率为97.62%,高于对照组的83.33%,差异有统计学意义(P<0.05)。治疗后,观察组FEV1、FVC高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组TNF-α、IL-6以及IgE水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组早晨与夜晚咳嗽评分比较差异无统计学意义(P>0.05);治疗后,观察组早晨咳嗽评分(1.15±0.26)分与夜晚咳嗽评分(1.43±0.24)分均低于对照组的(1.62±0.31)、(1.89±0.37)分,差异有统计学意义(P<0.05)。结论使用沙美特罗/氟替卡松联合孟鲁司特钠治疗成人咳嗽变异性哮喘可以有效改善患者肺功能,并且降低患者血清中炎症因子以及IgE表达水平。

Objective To discuss the clinical effect of salmeterol/fluticasone combined with montelukast sodium on adult cough variant asthma.Methods A total of 84 adults with cough variant asthma were divided into observation group and control group by simple random sampling method,with 42 cases in each group.The control group was treated by salmeterol/fluticasone,and the observation group was treated by montelukast sodium on the basis of the control group.The therapeutic effect,forced expiratory volume in the first second(FEV1)、forced vital capacity(FVC),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),immunoglobulin E(IgE)before and after treatment and morning and night cough symptom score were compared between the two groups.Results The total effective rate of treatment was 97.62%in the observation group,which was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).After treatment,the FEV1 and FVC in the observation group was higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6 and IgE in the observation group was lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in morning and night cough symptom score between the two groups(P>0.05).After treatment,the morning cough score(1.15±0.26)points and night cough score(1.43±0.24)points in the observation group were lower than(1.62±0.31)and(1.89±0.37)points in the control group,and their difference was statistically significant(P<0.05).Conclusion Salmeterol/fluticasone combined with montelukast sodium can improve the pulmonary function of adults with cough variant asthma,and reduce the level of inflammatory factors and IgE expression in the serum of patients.