生物标志物在冠心病诊断中的临床应用

Clinical application of biomarkers in the diagnosis of coronary heart disease

目的探讨联合检测低密度脂蛋白(LDL)、血清铁蛋白(SF)、C反应蛋白(CRP)对冠状动脉粥样硬化性心脏病(冠心病)的诊断价值。方法125例确诊为冠心病的患者作为冠心病组,100例非冠心病患者作为对照组。比较两组患者的SF、CRP、LDL水平,SF、CRP、LDL单项检测与三项联合检测冠心病的敏感性。结果冠心病组SF(275.30±80.31)μg/L、CRP(7.63±2.21)mg/L、LDL(3.79±0.82)mmol/L均高于对照组的(158.60±51.20)μg/L、(2.78±1.25)mg/L、(3.05±0.93)mmol/L,差异有统计学意义(P<0.05)。SF、CRP、LDL单项检测冠心病的敏感性分别为65%、77%、65%,低于三项联合检测的90%,差异有统计学意义(P<0.05)。结论血清LDL、SF、CRP联合检测有助于初筛冠心病。

Objective To discuss the value of combined detection of low density lipoprotein(LDL),serum ferritin(SF)and C-reactive protein(CRP)in the diagnosis of coronary heart disease.Methods LDL,SF and CRP were measured in 125 patients with coronary heart disease and 100 patients without coronary heart disease for statistical analysis.Results SF(275.3±80.31)μg/L,CRP(7.63±2.21)mg/L and LDL(3.79±0.82)mmol/L in coronary heart disease group was higher than(158.6±51.2)μg/L,(2.78±1.25)mg/L and(3.05±0.93)mmol/L in the control group,and their difference was statistically significant(P<0.05).The sensitivity of single detection of SF,CRP and LDL biomarkers in coronary heart disease group was 65%,77%and 65%,respectively,which was lower than 90%of the combined detection,the difference was statistically significant(P<0.05).Conclusion Combined detection of LDL,SF and CRP in serum is helpful for screening coronary heart disease.