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氢吗啡酮复合罗哌卡因髂筋膜阻滞对老年髋部骨折术患者血流动力学、镇静和镇痛的影响 被引量:19

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摘要 目的探讨氢吗啡酮复合罗哌卡因髂筋膜阻滞对老年髋部骨折术患者血流动力学、镇静和镇痛的影响。方法选择择期行单侧髋部骨折防旋股骨近端髓内钉内固定术(PFNA)的老年髋部骨折患者86例,运用随机数字表法随机分为观察组43例与对照组43例。对照组术前30 min给予罗哌卡因髂筋膜阻滞,观察组在对照组基础上给予氢吗啡酮注射液。比较两组术中出血量和手术时间,不同时刻血流动力学指标变化,术后3 h、12 h和24 h疼痛视觉模拟评分法(VAS)和Ramsay镇静评分变化,术前和术后24 h应激炎性因子变化。结果两组术中出血量和手术时间比较无明显差异(P>0.05)。两组麻醉诱导后(T1)和手术结束时(T2)时刻心率(HR)和平均动脉压(MAP)较麻醉诱导前(T0)时刻明显降低(P<0.05);观察组T1和T2时刻HR和MAP明显高于对照组(P<0.05)。观察组术后3 h、12 h和24 h VAS评分明显低于对照组(P<0.05)。观察组术后3 h、12 h和24 h Ramsay镇静评分明显高于对照组(P<0.05)。两组术后24 h血清皮质醇(Cor)、白细胞介素(IL)-6和去甲肾上腺素(NE)水平较术前明显升高(观察组:t=12.620、7.538、7.214,对照组:t=18.480、20.611、13.283,均P<0.05);观察组术后24 h血清Cor、IL-6和NE水平明显低于对照组(t=11.257、11.862、8.353,均P<0.05)。结论氢吗啡酮复合罗哌卡因髂筋膜阻滞对老年髋部骨折术患者血流动力学影响小,具有明显的镇静和镇痛作用,且可减轻应激炎性反应。
作者 姚娜 赵丽艳
出处 《中国老年学杂志》 CAS 北大核心 2020年第6期1240-1243,共4页 Chinese Journal of Gerontology
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