血尿酸水平与老年帕金森病临床分期、抑郁及认知障碍相关性研究

The Correlation between Serum Uric Acid Levels and Clinical Stages,Depression,Cognitive Dysfunction in Senile Patients with Parkinson’s Disease

目的:探讨血尿酸水平与老年帕金森病(PD)患者临床分期、抑郁及认知功能的关系,并对相关因素进行分析。方法:选取2016年4月-2018年10月在我院门诊及住院部就诊的老年PD患者60例作为PD组,选择性别、年龄相匹配的60例健康体检者作为对照组,分析简易精神状态检查量表(MMSE)评分、汉密尔顿抑郁量表(HAMD)评分、PD病情Hoehn-Yahr分级与PD患者血清尿酸水平之间是否存在相关性。结果:PD组血尿酸水平为(233.25±56.23)μmo1/L,明显低于对照组(317.79±84.69)μmo1/L(P<0.001)。将PD组分为抑郁组(A1组)和无抑郁组(A2组)、认知功能障碍组(B1组)和无认知功能障碍组(B2组),A1、B1组血尿酸水平分别明显低于A2、B2组,两组差异分别存在非常显著性意义(P<0.001)。PD组病情Hoehn-Yahr分级按轻、中、重3组患者的血尿酸水平分别与对照组相比较,经LSD-t检验,并经Bonferroni校正,均显著低于对照组,差别均有统计学意义(P<0.05)。轻、中、重3组组间血尿酸水平相比较,差异均无统计学意义(P>0.05)。结论:老年PD患者血尿酸水平降低,降低的程度与PD病情轻重无相关。低血尿酸水平与老年PD患者的抑郁和认知功能障碍有关。

Objective:To explore the relationship between serum uric acid levels(s UA)and clinical stages,depression,cognitive function in elderly patients with Parkinson’s disease(PD),and to analyze the related factors about these.Methods:60 cases of elderly patients with PD admitted to the outpatient and inpatient department of our hospital from April 2016 to October 2018 were selected as the PD group,in the meanwhile,60 healthy senile persons matched it in terms of gender and age were selected as the control group.The correlation among the minimum mental state examination(MMSE)score,Hamilton depression scale(HAMD)score,Hoehn-Yahr grade of PD condition with s UA was statistically analyzed respectively.Results:The s UA of the PD group was(233.25±56.23)μmol/L,which was significantly lower than that of the control group(317.79±84.69)μmol/L,P<0.001.The PD group was divided into depression group(A1 group)and non-depression group(A2 group),cognitive dysfunction group(B1 group)and non-cognitive dysfunction group(B2 group).The s UA of A1 and B1 groups was significantly lower than that of A2 and B2 groups,and the difference between the two groups was statistically significant individually(P<0.001).The s UA of the patients in the PD group was significantly lower than that in the control group according to the Hoehn-Yahr grading in the light,medium and heavy groups(P<0.05).After LSD-t test and Bonferroni correction,the difference was statistically significant(P<0.05).There was no significant differences in s UA between the light,medium and heavy groups(P>0.05).Conclusion:The s UA of the elderly patients with PD were decreased,and the degree of decrease was not related to the severity of PD condition.Low s UA are associated with depression and cognitive impairment in elderly patients with PD.