基于单镜头反光式相机的视网膜血氧饱和度无创测量系统

A Non-Invasive Retinal Blood Oxygen Saturation Measurement System Based on the Single-Lens Reflex Camera

视网膜有着很高的氧代谢需求,当人体出现眼部病变或全身系统性疾病时,通常会出现对应的视网膜血氧代谢异常和功能紊乱。对于视网膜血管含氧情况的检测有着重要的临床价值。然而,目前商用和实验室开发的视网膜血氧饱和度无创检测仪器均采用科研级探测器,其价格昂贵,不利于仪器的大规模生产和销售。本研究设计了一种基于单镜头反射式相机(单反相机)的视网膜血氧饱和度无创测量系统,该系统基于眼底相机,以Nikon D70单反相机作为探测器,针对其较理想的光谱响应曲线,通过提取出其绿色和红色通道记录的视网膜成像结果,即可用于功能性的血氧饱和度的检测。本研究提出的方法为廉价版的视网膜血氧饱和度检测分析仪提供了新的思路。该系统的测量准确性和重复性良好,具有在临床上进一步进行研究和应用的潜力。

The retina is a biological tissue with high oxygen metabolism.When there is an ocular lesion or systemic disease of the human body,there are abnormal retinal blood oxygen metabolism and regulating disorders correspondingly.The measurement of retinal oxygen saturation level is of clinical significance.Currently,scientific-grade detectors are generally employed in both commercially developed instruments and laboratory prototypes that allow for the non-invasive detection of retinal oxygen saturation.However,these scientific-grade detectors are very expensive and to some extent it hinders the mass production and sales of the retinal oxygen saturation measurement instruments.In this study,a non-invasive retinal blood oxygen saturation measurement system was designed based on a fundus camera with the single-lens reflex(SLR)camera as the detector.Specifically,the Nikon D70 SLR camera was used as the detector in the system for its ideal spectral response curves of the green and red channels.By extracting the corresponding retinal imaging information on the green and red channels,the functional blood oxygen saturation could be further calculated through a lab developed software.The method proposed in this study offers a new idea for the economic version of the retinal oxygen saturation measurement system.The system is able to measure the oxygen saturation with good accuracy and repeatability,and it has the potential for further study and clinic applications associated with ophthalmic and systemic diseases.