摘要
为了提高现有胆道支架的降解程度,改善易移位和发生胆道再狭窄的现状,本文设计了一种新型可降解TAXOLP3/4HB-PCL胆道支架,确定了基本结构参数。根据正常成年人和不同年龄段儿童的胆管尺寸,设计出了5种直径的直管型可降解胆道支架。采用MTT法评价胆道支架所用P3/4HB-PCL材料对成纤维细胞的增殖影响,并将材料浸入PBS缓冲液中对其降解性进行分析。结果表明,P3/4HB-PCL材料细胞反应性极轻,生物相容性良好,在类人体环境的条件下,降解性能良好。
In order to increase the degradable degree of biliary stent and improve the situation of easy displacement and biliary restenosis of current biliary stent,a novel degradable biliary stent was designed with TAXOL-P3/4HB-PCL,and the structural parameter were established.A total of 5 diameters of biliary stent were designed according to the size of bile duct for adults and children of different ages.The effect of P3/4HB-PCL on the proliferation of fibroblasts was valued by MTT method.The degradability of P3/4HB-PCL was analyzed by immersing it in PBS buffer.The results showed that P3/4HB-PCL had slight reactivity with fibroblasts,good biocompatibility and good degradability in a human-like environment.
作者
张亮
马亚丽
邵雯
ZHANG Liang;MA Yali;SHAO Wen(Bidding and Supply Office,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an Shaanxi 710061,China;State Assets Management Office,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an Shaanxi 710061,China)
出处
《中国医疗设备》
2020年第3期52-55,共4页
China Medical Devices
基金
陕西省重点研发计划项目(2018GY-115,2018GY-174)。
