期刊文献+

替诺福韦酯单药治疗慢性乙型肝炎的临床效果及不良反应探讨 被引量:3

下载PDF
导出
摘要 目的探讨对慢性乙型肝炎患者选择替诺福韦酯单药治疗后获得的临床效果以及表现出的用药不良反应。方法选择我院2015年11月至2017年2月收治的82例慢性乙型肝炎患者作为实验对象;采用抽签法分组;研究治疗药物期间,对照组(41例):选择阿德福韦酯药物进行治疗;观察组(41例):选择替诺福韦酯药物进行治疗;最终就两组慢性乙型肝炎患者转氨酶复常率、HBV DNA阴转率以及用药不良反应发生率展开对比。结果同对照组慢性乙型肝炎患者转氨酶复常率(73.17%)以及HBV DNA阴转率(75.61%)对比,观察组(97.56%)、(97.56%)获得明显提升(P<0.05);同对照组慢性乙型肝炎患者用药不良反应发生率(21.95%)对比,观察组(2.44%)获得明显降低(P<0.05)。结论临床医师对于慢性乙型肝炎患者选择替诺福韦酯药物进行治疗,对于患者转氨酶复常率以及HBV DNA阴转率提升,用药不良反应发生率降低可以做出充分保证,从而促进慢性乙型肝炎患者的病情康复。
作者 周然
出处 《中国医药指南》 2020年第6期31-32,共2页 Guide of China Medicine
  • 相关文献

参考文献7

二级参考文献80

  • 1中华医学会肝病学分会 中华医学会感染病学分会.慢性乙型肝炎防治指南.中华肝脏病杂志,2010,19(1):3760-3769.
  • 2European Association For the Study of The Liver. EASL clinical practice guidelines:management of chronic hepatitis B virus infection[J]. J Hepatol, 2012, 57(1):167-185.
  • 3Liaw YF, Kao JH, Piratvisuth T, et al. Asian-Pacific consensus statement on the management of hronic hepatitis B:a 2012 update[J]. Hepatol Int, 2012, 6(3):531-561.
  • 4Hu CY, Liu YM, Liu Y, et al. Pharmacokinetics and tolerability of tenofovir disoproxil fumarate 300 mg once daily:an open-label,single- and multiple-dose study in healthy chinese subjects[J]. Clin Ther, 2013, 35(12):1884-1889.
  • 5Gordon SC, Krastev Z, Horban A, et al. Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load[J]. Hepatology, 2013, 58(2):505-513.
  • 6Liaw YF, Sheen IS, Lee CM, et al. Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease[J]. Hepatology, 2011, 53(1):62-72.
  • 7Marcellin P, Gane EJ, Tsai N, et al. Seven years of treatment with tenofovir DF for chronic hepatitis B virus infection is safe and well tolerated and associated with sustained virological, biochemical and serological responses with no detectable resistance[J]. Hepatology, 2013, 58(S):649A".
  • 8Hou JL, Gao ZL, Xie Q, et al. Continued use of tenofovir disoproxil fumarate monotherapy or switching from adefovir dipivoxil results in potent viral suppression and a favorable safety profile in Chinese patients with chronic hepatitis B[J]. Hepatol Int, 2014, 8(S):S147.
  • 9Lee CI, Kwon SY, Kim JH, et al. Efficacy and safety of tenofovir-based rescue therapy for chronic hepatitis B patients with previous nucleo(s/t)ide treatment failure[J]. Gut Liver, 2014, 8(1):64-69.
  • 10Langness JA, Hindman JT, Johnson SC, et al. The frequency of adjusted renal dosing of tenofovir DF and its effects on patient outcomes[J]. J Pharm Pract, 2013, 26(4):397-400.

共引文献131

同被引文献35

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部