血清IL-6、hs-CRP及Hcy水平对不同分型脑梗死的影响研究

Effect of serum IL-6,hs-CRP and Hcy levels on different types of cerebral infarction

目的 探讨不同分型脑梗死患者血清白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平变化及临床意义。方法 选取2017年1月至2018年6月该院住院治疗的脑梗死患者96例作为脑梗死组,同时选取体检健康者49例作为对照组。比较两组患者及不同分型脑梗死患者血清IL-6、hs-CRP和Hcy水平变化。结果 脑梗死组血清IL-6、hsCRP、Hcy水平明显高于对照组,差异均有统计学意义(P<0.05)。大动脉粥样硬化型患者IL-6、hs-CRP、Hcy水平高于小动脉闭塞型、心源性脑栓塞型及不明原因型患者,差异均有统计学意义(P<0.05)。结论 IL-6、hs-CRP和Hcy共同参与了缺血性脑血管病的发生。

Objective To investigate the changes of serum interleukin-6(IL-6),high sensitive C reactive protein(hs-CRP)and homocysteine(Hcy)levels in patients with different types of cerebral infarction and their clinical significance.Methods January 2017 to June 2018,96 patients with cerebral infarction who were hospitalized in the hospital were selected as the cerebral infarction group,while 49 healthy people were selected as the control group.The changes of serum IL-6,hs-CRP and Hcy in two groups and different types of cerebral infarction were compared.Results The levels of IL-6,hs-CRP and Hcy in the cerebral infarction group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The levels of IL-6,hs-CRP and Hcy in patients with large atherosclerosis were higher than those in patients with small artery occlusion,cardiogenic cerebral embolism and Unexplained,the differences were statistically significant(P<0.05).Conclusion IL-6,hs-CRP and Hcy are involved in the occurrence of ischemic cerebrovascular disease.