抑酸剂对危重脑出血患者医院获得性肺炎的影响

Effect of antacids on hospital-acquired pneumonia in patients with critical cerebral hemorrhage

目的探讨抑酸剂对危重脑出血患者应激性胃溃疡(SU)与医院获得性肺炎(HAP)的影响。方法选取我院ICU重症患者100例,根据抑酸剂使用类型将其分为质子泵抑制剂组(PPI组)和H2受体拮抗剂组(H2RA组)。分析两组的SU、HAP发生率,并根据PPI使用疗程将使用1~3 d列入A组,4~7 d列入B组,8~14 d列入C组,分析PPI疗程对SU、HAP发生率的影响。结果H2RA组SU发生率显著高于PPI组(P<0.05)。C组SU发生率显著低于A组(P<0.05),但HAP发生率稍高于A组(P>0.05);C组患者的HAP发生率高于B组(P<0.05)。结论危重脑出血患者应常规给予PPI预防SU,适当疗程的PPI治疗可以降低SU、HAP的发生率。

Objective To investigate the effects of antacids on stress ulcer(SU) and hospital-acquired pneumonia(HAP)in patients with critical cerebral hemorrhage.Methods A total of 100 severe patients in ICU of our hospital were selected and divided into proton pump inhibitor group(PPI group) and H2 receptor antagonists group(H2 RA group) according to the type of antacid.The incidence of SU and HAP in the two groups were analyzed.According to the course of PPI use,the patients who treated for 1-3 days were included in group A,group B for 4-7 days,and group C for 8-14 days.The effect of PPI course on the incidence of SU and HAP were analyzed.Results The incidence of SU in the H2 RA group was significantly higher than that in the PPI group(P<0.05).The incidence of SU in the group C was significantly lower than that in the group A(P<0.05),but the incidence of HAP in the group C was slightly higher than that in the group A(P>0.05).The incidence of HAP in the group C was higher than that in the group B(P<0.05).Conclusion The patients with critical cerebral hemorrhage should be given PPI regularly to prevent SU.Proper course of PPI treatment can reduce the incidence of SU and HAP.