氯米芬联合人绝经期促性腺激素治疗多囊卵巢综合征不孕症的临床效果

Clinical effect of clomiphene combined with human menopausal gonadotropin in the treatment of polycystic ovary syndrome infertility

目的探究氯米芬联合人绝经期促性腺激素治疗多囊卵巢综合征(PCOS)不孕症的临床效果。方法选择2017年6月至2018年6月收治的80例PCOS不孕症患者为研究对象,使用简单随机法将其分成对照组和观察组,每组40例。对照组给予常规治疗,观察组给予氯米芬联合人绝经期促性腺激素治疗。比较两组患者的治疗效果。结果治疗后,两组患者LH、FSH、E2、T水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组卵巢体积小于对照组,优质卵泡数、成熟卵泡数、排卵数及窦卵泡数均多于对照组,卵泡期、黄体期的内膜厚度均大于对照组,差异具有统计学意义(P<0.05)。两组患者的排卵率、流产率、多胎妊娠率比较,差异无统计学意义(P>0.05);观察组卵巢过度刺激综合征发生率低于对照组,妊娠率高于对照组,差异具有统计学意义(P<0.05)。结论氯米芬联合人绝经期促性腺激素治疗PCOS不孕症患者效果确切,值得临床应用。

Objective To explore the clinical effect of clomiphene combined with human menopausal gonadotropin in the treatment of polycystic ovary syndrome(PCOS) infertility.Methods From June 2017 to June 2018,80 infertile patients with PCOS were selected as the study objects.The patients were divided into control group and observation group by simple random method,with 40 cases in each group.The control group was given routine treatment,and the observation group was treated with clomiphene combined with human menopausal gonadotropin.The therapeutic effects of the two groups were compared.Results After treatment,the levels of LH,FSH,E2 and T in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The ovarian volume of the observation group was smaller than that of the control group,the numbers of high-quality follicles,mature follicles,ovulation and antral follicles were more than those of the control group,and the endometrial thickness of the follicular and luteal periods were greater than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in ovulation rate,abortion rate and multiple pregnancy rate between the two groups(P>0.05);the incidence of ovarian hyperstimulation syndrome in the observation group was lower than that in the control group,and the pregnancy rate was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion Clomiphene combined with human menopausal gonadotropin in the treatment of PCOS infertility is effective and worthy of clinical application.