孕晚期母体血清IL-2、sIL-2R、P-LAP联合检测对早产的预测价值

Predictive value of combined detection of maternal serum IL-2, sIL-2R and P-LAP in late pregnancy to preterm delivery

目的探讨孕晚期母体血清白细胞介素-2(IL-2)、可溶性白细胞介素2受体(s IL-2R)、胎盘亮氨酸氨基肽酶(P-LAP)联合检测对早产的预测价值。方法回顾性分析2018年1月至2019年1月于我院分娩的356例产妇的临床资料,根据是否早产将其分为早产组(48例,分娩时孕周<37周)与非早产组(308例,分娩时孕周≥37周),产妇均于孕晚期检测血清IL-2、s IL-2R、P-LAP水平,并随访至分娩。比较两组产妇的血清IL-2、s IL-2R、P-LAP水平,并分析血清IL-2、s IL-2R、P-LAP联合检测对早产的预测效能。结果早产组血清IL-2、s IL-2R水平显著高于非早产组,血清P-LAP水平显著低于非早产组,差异具有统计学意义(P<0.05)。受试者工作特征曲线(ROC)显示,血清IL-2、s IL-2R、P-LAP联合检测预测早产的特异度和AUC均高于血清IL-2、s IL-2R、P-LAP单独预测。结论早产产妇孕晚期母体血清IL-2、s IL-2R、P-LAP水平存在异常情况,三者联合检测可作为早产的有效预测方式。

Objective To explore the predictive value of combined detection of maternal serum interleukin-2(IL-2),soluble interleukin-2 receptor(sIL-2 R) and placenta leucine aminopeptidase(P-LAP) in late pregnancy to preterm delivery.Methods The clinical data of 356 parturients who delivered in our hospital from January 2018 to January 2019 were analyzed retrospectively.According to whether preterm delivery or not,the parturients were divided into preterm group(48 cases,gestational age <37 weeks at delivery) and non-preterm group(308 cases,gestational age≥37 weeks at delivery).Combined detection the levels of serumIL-2、sIL-2 R、P-LAP were detected in the late pregnant and followed up until delivery.The levels of serum IL-2,sIL-2 R and P-LAP in the two groups were compared,and the predictive effect of the combined detection of serum IL-2,sIL-2 R and P-LAP to preterm delivery was analyzed.Results The levels of serum IL-2 and sIL-2 R in the preterm group were significantly higher than those in the non-preterm group,and the level of serum PLAP was significantly lower than that in the non-preterm group,the differences were statistically significant(P<0.05).Receiver operating characteristic curve(ROC) showed that the specificity and AUC of the combined detection of serum IL-2,sIL-2 R and P-LAP were higher than those of detection of serum IL-2,sIL-2 R and P-LAP alone.Conclusion The levels of maternal serum IL-2,sIL-2 R and P-LAP were abnormal in the late pregnant women with preterm delivery.The combined detection of the three indexes can be used as an effective prediction method for preterm delivery.