摘要
脑卒中是世界上主要的致死和致残的原因之一,缺血性脑卒中(IS)约占所有脑卒中案例的87%。由于IS存在黄金3或4.5 h的治疗窗,其早期筛查和快速诊断显得尤为重要。分子标志物的发现为IS的预测和诊断提供了新的思路。质谱技术可以快速灵敏地检测生物医学样本中的各种化合物,已被广泛应用于IS生物标志物的发现。该综述总结和讨论了质谱在IS标志物(特别是蛋白和小分子代谢物标志物)发现中的应用及其最新进展。
Stroke is one of the leading causes for death and disability in the world,while ischemic stroke(IS)constitutes around 87 percent of stroke cases.Medical treatment should typically be made within 3 or 4.5 hours of stroke onset.Rapid diagnosis and early screening on IS are thus of great significance,and molecular biomarker is an effective strategy for this.Mass spectrometry is a choice of technique for detection of various compounds in biomedical samples,and has played important roles in discovery of biomarkers for IS.In this review,the recent advances in discovering biomarkers of IS,particularly those of the protein and metabolite biomarkers,are summarized and commented.
作者
王健莹
吴茜
姚钟平
WANG Jian-ying;WU Qian;YAO Zhong-ping(State Key Laboratory of Chemical Biology and Drug Discovery,Food Safety and Technology Research Centre,Department of Applied Biology and Chemical Technology,Tlie Hong Kong Polytechnic University,Hung Hom,Kowloon,Hong Kong,China;State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation),Shenzhen Key Laboratory of Food Biological Safety Control,Shenzhen Research Institute of The Hong Kong Polytechnic University,Shenzhen 518057,China)
出处
《分析测试学报》
CAS
CSCD
北大核心
2020年第1期44-49,共6页
Journal of Instrumental Analysis
基金
国家自然科学基金项目(81874306)。
