组织工程皮肤现状与挑战

Status and challenges of tissue-engineered skin

自体断层皮片移植仍是修复皮肤缺损的重要方法,但存在一些明显的不足,如供皮区损伤、皮源不足等。研发组织工程皮肤实现缺损皮肤的永久性替代是一个理想目标。经过几十年的发展,多种组织工程皮肤已被投入市场使用,但要实现皮肤缺损的再生修复还有很长的路要走。本文总结组织工程皮肤的现状,并对组织工程皮肤发展所面临的机遇和挑战做初步探讨。

Autologous split-thickness skin grafting is still an important procedure for the repair of skin defect.However,there are some obvious limitations,such as new injury to skin donor sites and insufficient skin source,etc.It is an ideal goal to develop tissue-engineered skin to realize permanent replacement of skin defect.After decades of development,a variety of tissue-engineered skins have been put into the market for applications,but it is still a long way to achieve regenerative repair of skin defect.In this article,we summarize the status of various tissue-engineered skins,and then make a preliminary discussion on the opportunities and challenges on development of tissue-engineered skin.