摘要
碳酸钙和冰乙酸在水中反应得到乙酸钙溶液,室温下加入约2.5倍体积的95%乙醇,静置2~4 h,以300目滤布挤压过滤,滤液浓缩后重复操作1次,合并2次所得乙酸钙,80℃热风循环干燥3 h,即得乙酸钙纯品,收率可达82%以上。本工艺产品中镁含量大大降低,质量指标符合美国药典(USP40)要求。
Calcium acetate solution was prepared from calcium carbonate and glacial acetic acid in water. Adding about 2.5 times of the volume of 95% ethanol as much as the above solution at room temperature, then the mixture was settled for 2-4 h and filtered with 300 mesh filtration fabric. After concentration, the above operation was repeated once. The precipitate combined was dried at 80 ℃ for 3 h to obtain the purified calcium acetate, and the total yield was above 82%. The magnesium content in the purified calcium acetate was significantly decreased. It was concluded that the final product was consistent with the quality specification of calcium acetate in US pharmacopoeia(USP40).
作者
钱如贵
袁玲玲
丁丽娜
李凤
陈龙芳
QIAN Rugui;YUAN Lingling;DING Lina;LI Feng;CHEN Longfang(Kunming Bangyu Pharmaceutial Co.,Ltd.,Kunming 650211)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2020年第2期270-275,共6页
Chinese Journal of Pharmaceuticals
关键词
碳酸钙
乙酸钙
乙醇沉淀
纯化
calcium carbonate
calcium acetate
ethanol precipitation
purification