肿瘤相关中性粒细胞调控胃癌发展的研究进展

Recent advances in tumor-associated neutrophils regulate the progression of gastric cancer

胃癌是全球范围内病死率极高的恶性肿瘤,5年生存率很低。近年来,免疫治疗应用于癌症的效果渐渐被人们所重视。肿瘤免疫微环境中的中性粒细胞与胃癌的侵袭、发展及预后相关。肿瘤相关中性粒细胞可分为抑瘤和促瘤两种表型,抑瘤型可激活相关的细胞因子发挥杀伤肿瘤细胞的作用,促瘤型可分泌相关化学因子促进肿瘤发生发展、影响疾病的预后。文章就肿瘤相关中性粒细胞调控胃癌发展的机制进展进行综述。

Gastric cancer, which has very low 5-year survival rate, is a malignant tumor with high mortality around the world. In recent years, increasing attention has been paid to the effect of immunotherapy on cancer.Neutrophils in tumor immune microenvironment are associated with invasion, progression and prognosis of gastric cancer. Tumor-associated neutrophils can be classified into tumorsuppressor phenotype and tumorpromotion phenotype. Tumorsuppressor type can activate related cytokines to inhibit or kill tumor cells, while tumorpromotion type can secrete related chemical factors to promote the formation and progression of tumorand affect the prognosis of disease. This article reviews the mechanism of tumor-associated neutrophils in regulating the progression of gastric cancer.