益气养阴、化痰通络方治疗冠心病合并2型糖尿病PCI术后心绞痛临床研究

Clinical efficacy of angina pectoris after pci in patients with coronary heart disease complicated with type 2 diabetes by yiqi yangyin and huatan tongluo recipe

目的:从临床疗效上评估益气养阴、化痰通络方对改善冠心病合并2型糖尿病经皮冠状动脉介入治疗(PCI)术后患者心绞痛症状及心功能、微循环、炎症反应的影响。方法:将冠心病合并2型糖尿病PCI术后62例患者随机分为治疗组和对照组,每组均有31例患者。两组均予以西药基础治疗,治疗组在此基础上加用益气养阴、化痰通络方颗粒剂。分析两组1个疗程后代谢当量(METs)、心绞痛症状、中医症候疗效、B型钠尿肽(BNP)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、左室射血分数(LVEF)及3个月后校正的冠脉TIMI帧数计数(CTFC)的变化。结果:治疗后治疗组METs、LVEF提高优于对照组(P<0.05);治疗组BNP、hs-CRP、IL-6、TNF-α、CTFC的改善优于对照组;治疗组心绞痛疗效优于对照组;治疗组中医症候改善的有效率优于对照组。结论:益气养阴、化痰通络方能有效缓解冠心病合并2型糖尿病PCI术后患者心绞痛症状,提高患者心功能,抑制炎症反应,改善微循环障碍。

Objective: To evaluate the clinical efficacy of Yiqi Yangyin and Huatan Tongluo Recipe in improving the symptoms of angina pectoris and cardiac function in patients with coronary heart disease complicated with type 2 diabetes after PCI.Methods:Totally 62 patients with coronary heart disease complicated with type 2 diabetes after PCI were randomly divided into treatment group and control group,with 31 patients in each group.Both groups were treated with western medicine.The treatment group added Yiqi Yangyin and Huayu Tongluo Recipe granules.The changes of metabolic equivalent(METs),angina symptoms,TCM symptoms,BNP,hypersensitive C-reactive protein(hs-CRP),Interleukin-6(IL-6),Tumor necrosis factor-α(TNF-α)and left ventricular ejection fraction(LVEF)after 1 course of treatment as well as corrected TIMI Frame Count(CTFC)after six month were analyzed.Results:The improvement of METS and LVEF in the treatment group was better than that in the control group(P<0.05);the improvement of BNP,hs-CRP,IL-6,TNF-αand CTFC in the treatment group was better than that in the control group;the curative effect of angina pectoris in the treatment group was better than that in the control group;the effective rate of TCM syndrome improvement in the treatment group was better than that in the control group.Conclusion:Yiqi Yangyin and Huatan Tongluo Recipe can effectively alleviate angina pectoris symptoms in patients with coronary heart disease complicated with type 2 diabetes after PCI,suggesting cardiac function,inhibiting inflammatory response,and improving microcirculation disturbance.