肾小管损伤在急性肾损伤向慢性肾病转变中的作用

The role of renal tubular Injury in the transition from acute kidney injury to chronic kidney disease

急性肾损伤(AKI)是严重威胁人类健康、甚至生命的急危重肾病,可导致慢性肾疾病(CKD)、终末期肾病(ESRD)的发生,造成了全球公共卫生问题。AKI向CKD转变的机制目前尚未完全阐明,肾小管损伤可能发挥重要作用。文章就肾小管损伤在AKI向CKD转变中的作用,将从细胞去分化、炎性细胞浸润、缺氧与血管密度下降、线粒体功能障碍与氧化应激、G 2/M细胞周期阻滞、自噬、TGF-β信号通路及Wnt信号通路等方面进行综述。

Acute kidney injury(AKI)is an acute and critical kidney disease that seriously threatens human health and even life.It can lead to the chronic kidney disease(CKD)and end-stage kidney disease(ESRD),causing global public health problems.At present,the transition mechanism from AKI to CKD has not been fully elucidated,and renal tubular injury may play an important role in it.This paper reviews the role of renal tubular injury in the transition from AKI to CKD including cell dedifferentiation,inflammatory cell infiltration,hypoxia and vascular density decline,mitochondrial dysfunction and oxidative stress,G 2/M cell cycle arrest,autophagy,TGFβsignaling pathway and Wnt signaling pathway.