巨噬细胞在非酒精性脂肪性肝病中的作用

Research advances in the role of macrophages in nonalcoholic fatty liver disease

随着生活水平的提高,非酒精性脂肪性肝病(NAFLD)发病率逐年升高并且趋于年轻化,但其具体发病机制尚未明确。巨噬细胞作为参与NAFLD发病的重要细胞之一,一直广受关注。针对肝脏巨噬细胞的来源及分类、巨噬细胞在NAFLD肝脏炎症中的作用和其活化的机制、靶向巨噬细胞药物进行阐述,旨在为临床治疗NAFLD提供参考。

With the improvement of living standard,the incidence rate of nonalcoholic fatty liver disease(NAFLD)is gradually increasing year by year and its age of onset tends to become younger,but its pathogenesis remains unclear.Macrophages are important cells involved in the pathogenesis of NAFLD and have attracted great attention.This article elaborates on the origin and classification of liver macrophages,the role of macrophages in liver inflammation and related activation mechanism,and the drugs targeting macrophages,in order to provide a reference for the clinical treatment of NAFLD.