线粒体与肝细胞损伤的关系

Association between mitochondria and hepatocellular injury

在肝脏组织中,线粒体不但为肝细胞的物质代谢提供了能量,同时还广泛参与了肝细胞损伤甚至凋亡的过程,在与肝细胞损伤、凋亡密切相关的肝炎、肝纤维化、肝癌癌前病变及肝癌的病理过程中也发挥了重要的作用。从线粒体膜通透性的改变在肝细胞损伤中的重要作用、ATP合成障碍及消耗加速肝细胞损伤以及肝细胞线粒体Ca 2+稳态异常与肝细胞损伤关系等方面阐述了线粒体与肝细胞损伤之间的关系,以期以线粒体为靶点,为防治肝细胞损伤引起的慢性肝脏疾病提供理论依据。

The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes,but also participates in hepatocellular injury and even apoptosis.It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis,such as hepatitis,hepatic fibrosis,precancerous lesion,and liver cancer.This article elaborates on the association between mitochondria and hepatocellular injury from the following aspects:the important role of the change in mitochondrial membrane permeability in hepatocellular injury,hepatocellular injury accelerated by ATP synthesis disorder and consumption,and the association of abnormal Ca 2+homeostasis in hepatocellular mitochondria with hepatocellular injury,in order to provide a theoretical basis for mitochondria-targeted prevention and treatment of chronic liver diseases due to hepatocellular injury.